Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells

ABSTRACT: Polycomb group (PcG) proteins are transcriptional repressors with a central role in the establishment and maintenance of gene expression patterns during development. We have investigated the role of Polycomb Repressive Complexes (PRCs) in hematopoietic stem cells (HSCs) and progenitor populations. We show that mice with loss of function mutations in PRC2 components display enhanced HSC/progenitor population activity, whereas mutations that disrupt PRC1 or PhoRC are associated with HSC/progenitor cell defects. Since the hierarchical model of PRC action would predict synergistic effects of PRC1 and PRC2 mutation, these opposing effects suggest this model does not hold true in HSC/progenitor cells. To investigate the molecular targets of each complex in HSC/progenitor cells, we measured genom

ORGANISM(S): Mus musculus

SUBMITTER: Matthew Ritchie 

PROVIDER: E-GEOD-21404 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress