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TranscriptomicsTranscription profiling of fission yeast SAGA mutants shows that the SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8
The SAGA complex is a conserved multifunctional coactivator known to play broad roles in eukaryotic transcription. To gain new insights into its functions, we have performed biochemical and genetic analyses of SAGA in the fission yeast, Schizosaccharomyces pombe. Purification of the S. pombe SAGA ...
ORGANISM(S): Schizosaccharomyces pombe 
2008-11-19 | E-MTAB-53 | biostudies-arrayexpress
UnknownProduction and radiochemistry of the in vivo PET generator <sup>140</sup>Nd/<sup>140</sup>Pr as an imaging surrogate for F-block therapeutic radionuclides.
Not available
S-EPMC12504599 | biostudies-literature
ProteomicsSelective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by activating a shunt pathway that generates the toxic metabolite 24(S),25-epoxycholesterol
LUM2_708738 - MM0299-probe bound protein; LUM2_708739 - MM0299 competition; LUM2_850369 - Ro-alkyne bound protein; LUM2_850370 - Ro 48-8071 competition
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-01-11 | MSV000091046 | MassIVE
TranscriptomicsTranscription profiling of fission yeast strains identifies widespread requirement for SWI/SNF and RSC on transcription
SWI/SNF chromatin remodeling complexes play critical roles in transcription and other chromatin-related processes. The analysis of the two members of this class in Saccharomyces cerevisiae, SWI/SNF and RSC, has heavily contributed to our understanding of these complexes. To understand the in vivo ...
ORGANISM(S): Schizosaccharomyces pombe 
2008-06-13 | E-MTAB-31 | biostudies-arrayexpress
UnknownRecent acquisition of imprinting at the rodent Sfmbt2 locus correlates with insertion of a large block of miRNAs.
Not available
S-EPMC3110154 | biostudies-literature
UnknownGTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf.
Not available
S-EPMC7596874 | biostudies-literature
TranscriptomicsTranscription profiling of fission yeast wild type and yox1 mutant strains
Transcription profiling of fission yeast /yox1/ deletion and genome wide location analysis of Yox1p and Cdc10p transcription factors reveal a negative feedback interaction: /yox1 /is transcriptionally activated by MBF, and Yox1p in turn transcriptionally represses the MBF target genes (including /yo...
ORGANISM(S): Schizosaccharomyces pombe 
2009-08-20 | E-TABM-646 | biostudies-arrayexpress
no omics definedA coordintate global control over cellular transcription
Although much is known about the regulation of eukaryotic transcription, the global controls which determine rates of total transcription within a cell are not well understood. We have investigated the effects that the DNA to protein ratio has on both total cellular transcription and the transcripti...
ORGANISM(S): Schizosaccharomyces pombe 
2011-09-23 | E-TABM-1075 | biostudies-arrayexpress
TranscriptomicsTranslation profiling of Schizosaccharomyces pombe size separated polysome fractions provides data on average numbers of associated ribosomes for most transcripts
To obtain translational profiles for all mRNAs, polysome preparations are separated according to their size using a sucrose gradient and the mRNAs in each fraction are identified and quantified with DNA microarrays. Starting with exponentially growing cells, we analyzed 12 polysome fractions using D...
ORGANISM(S): Schizosaccharomyces pombe 
2007-03-22 | E-TABM-222 | biostudies-arrayexpress
UnknownEndovascular versus open surgical endarterectomy for atherosclerotic lesions of the common femoral artery (CFA)
Not available
S-EPMC7045407 | biostudies-literature
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