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MetabolomicsBiochemical Profiling of the Brain and Blood Metabolome in a Mouse Model of Prodromal Parkinson’s Disease Reveals Distinct Metabolic Profiles (MS assays)
Parkinson’s disease is the second most common neurodegenerative disease. In the vast majority of cases the origin is not genetic and the cause is not well understood, although progressive accumulation of α-synuclein aggregates appears central to the pathogenesis. Currently, treatments that slow dise...
2019-02-07 | MTBLS674 | MetaboLights
MetabolomicsBiochemical Profiling of the Brain and Blood Metabolome in a Mouse Model of Prodromal Parkinson’s Disease Reveals Distinct Metabolic Profiles (NMR assay)
Parkinson’s disease is the second most common neurodegenerative disease. In the vast majority of cases the origin is not genetic and the cause is not well understood, although progressive accumulation of α-synuclein aggregates appears central to the pathogenesis. Currently, treatments that slow dise...
2019-02-07 | MTBLS640 | MetaboLights
TranscriptomicsTranscription profiling of human peripheral blood to detect cardiac allograft rejection and response to immunosuppressive therapy
BACKGROUND: Assessment of gene expression in peripheral blood may provide a noninvasive screening test for allograft rejection. We hypothesized that changes in peripheral blood expression profiles would correlate with biopsy-proven rejection and would resolve after treatment of rejection episodes. M...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-5967 | biostudies-arrayexpress
TranscriptomicsTranscription start site identification in wild type Escherichia coli
RNAseq was used to map transcription start sites globally in wild type Escherichia coli. Total RNA was isolated from cells grown in LB media until exponential phase.
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2021-04-16 | E-MTAB-9655 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of nasal polyp derived human IL17RB positive and negative T-helper cells
Background: Chronic rhinosinusitis with nasal polyposis (CRSwNP) in western countries is characterized by eosinophilia, IgE production and Th2 cytokine expression. Type 2 innate lymphoid cells (ILC2) from polyps produce IL-5 and IL-13 in response to IL-25 and IL-33 although the relevance of this axi...
ORGANISM(S): Homo sapiens 
2015-12-22 | E-GEOD-70898 | biostudies-arrayexpress
TranscriptomicsDeciphering the molecular immune response to COVID-19 using single cell multi-omics
Multi-omics single-cell profiling of surface proteins, gene expression and lymphocyte immune receptors from hospitalised COVID-19 patient peripheral blood immune cells and healthy controls donors. Identification of the coordinated immune cell compositional and state changes in response to SARS-CoV-2...
ORGANISM(S): Homo sapiens 
2021-03-17 | E-MTAB-10026 | biostudies-arrayexpress
MetabolomicsFatty acid synthesis in colorectal cancer: characterization of lipid metabolism in serum, tumour, and normal host tissues
The objective of the experiment was to compare serum fatty acid metabolite abundance between individuals with varying clinical stages of colorectal cancer (stage I-IV) and age-and-gender matched disease-free controls. Fatty acid metabolite abundance was compared between locoregional (stage I-III) an...
2016-12-15 | MTBLS27 | MetaboLights
TranscriptomicsTranscription profiling of hypertension induced with chronic or acute angiotensin treatment in mouse, 2
Hypertension induced with chronic or acute angiotensin treatment in mouse. Related experiment E-TIGR-11
ORGANISM(S): Mus musculus 
2005-01-01 | E-TIGR-12 | biostudies-arrayexpress
UnknownHematologic disorder-associated Cxcr4 gain-of-function mutation leads to uncontrolled extrafollicular immune response.
Not available
S-EPMC8176768 | biostudies-literature
TranscriptomicsEpigenetic and immune function profiles associated with post-traumatic stress disorder
The biological underpinnings of post-traumatic stress disorder (PTSD) have not been fully elucidated. Previous work suggests that alterations in the immune system are characteristic of the disorder. Identifying the biological mechanisms by which such alterations occur could provide fundamental insig...
ORGANISM(S): Homo sapiens 
2010-05-12 | E-GEOD-21282 | biostudies-arrayexpress
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