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MetabolomicsUnexpected similarities between the Schizosaccharomyces and human blood metabolomes, and novel human metabolites (Blood fraction)
Metabolomics, a new branch of chemical biology, provides compositional and quantitative information about the state of organism or cell at the levels of metabolite constituents. We here report non-targeted metabolome of human blood that is made up of plasma and red blood cells (RBCs), using liquid-c...
2014-07-08 | MTBLS87 | MetaboLights
MetabolomicsUnexpected similarities between the Schizosaccharomyces and human blood metabolomes, and novel human metabolites (Blood plasma and RBC fractions)
Metabolomics, a new branch of chemical biology, provides compositional and quantitative information about the state of organism or cell at the levels of metabolite constituents. We here report non-targeted metabolome of human blood that is made up of plasma and red blood cells (RBCs), using liquid-c...
2014-07-08 | MTBLS88 | MetaboLights
TranscriptomicsEffects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study
The hypothesis was that 6 months of dietary n-3 FA supplementation to humans affected expression of genes that might be of significance for inflammatory processes and for Alzheimer´s disease. Effects on global gene expression profiles (Affymetrix Human Focus array) in human blood mononuclear leukocy...
ORGANISM(S): Homo sapiens 
2012-05-23 | E-GEOD-29680 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human peripheral blood leukocytes from CHASRS particpants
Gene expression profiling was carried out on peripheral blood leukocytes from 14 healthy older adults. The primary research question is whether gene expression differs in individuals experiencing chronically high levels of social isolation (by UCLA Loneliness Scale) vs chronically low levels of soc...
ORGANISM(S): Homo sapiens 
2009-04-23 | E-GEOD-7148 | biostudies-arrayexpress
TranscriptomicsWhole-transcriptome high-throughput RNA sequencing of blood leukocytes from Parkinson's disease human patients pre- and post-deep brain stimulation
The given data set is the first deep sequencing transcriptome-wide data set of human Parkinson's disease (PD) patients RNA. The data set was produced from blood leukocytes of PD patients, from the same patients following deep brain stimulation (DBS), and from matched healthy control volunteers. Post...
ORGANISM(S): Homo sapiens 
2014-07-16 | E-GEOD-42608 | biostudies-arrayexpress
ProteomicsThe LC-MS/MS analysis of human leukocytes in atherosclerosis related and non-related to chronic kidney disease
We performed quantitative and qualitative proteomic analysis by nanoLC-MS/MS to study the global changes in proteome of leukocytes isolated from peripheral blood of patients in various stages of chronic kidney disease and cardiovascular disease as compared to healthy controls.
ORGANISM(S): Homo sapiens (Human) 
2021-04-30 | PXD018596 | Pride
Chronic kidney disease Cardiovascular disease Leukocytes Atherosclerosis Human Lc-ms/ms 
ProteomicsBlood leukocytes recapitulate diabetogenic peptide-MHC-II complexes displayed in the pancreatic islets
Assessing the self-peptides presented by susceptible major histocompatibility complex (MHC) molecules is crucial for evaluating the pathogenesis and therapeutics of tissue-specific autoimmune diseases. However, direct examination of such MHC-bound peptides displayed in the target organ remains large...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-26 | PXD024400 | Pride
Blood leukocytes Nod mouse Mhc-ii peptidome 
TranscriptomicsTranscription profiling of rat peripheral blood leukocytes treated with the estrogen receptor agonists estradiol, PPT and DPN to investigates the functional roles of estrogen receptor alpha and beta
This experiment investigates the functional roles of estrogen receptor alpha and beta in peripheral blood leukocytes by using selective estrogen receptor agonists. The agonists that are used are estradiol (E2), the selective ER-alpha agonist PPT (4,4',4''-(4-Propyl-[1H]-pyrazole-1,3,5-triyl)trisphen...
ORGANISM(S): Rattus norvegicus 
2007-05-30 | E-TABM-269 | biostudies-arrayexpress
TranscriptomicsIndividual-specific variation of gene expression in peripheral blood leukocytes
DNA microarray technology is used to determine gene expression profiles of various cell types, especially abnormal cells, such as cancer. By contrast, relatively little attention has been given to expression profiling of normal tissues. Here we describe studies of gene expression in peripheral blood...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-838 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human blood leukocytes to discriminate patients with acute infections
Each infectious agent represents a unique combination of pathogen-associated molecular patterns that interact with specific pattern-recognition receptors expressed on immune cells. Therefore, we surmised that the blood immune cells of individuals with different infections might bear discriminative t...
ORGANISM(S): Homo sapiens 
2009-03-13 | E-GEOD-6269 | biostudies-arrayexpress
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