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Macrophages are essential in immune defence, tissue development, and disease onset and progression. Their function is in part dictated by their microenvironment and origin. Tissue-resident macrophages originate from yolk sac progenitors, persisting in adult organs and tissues mainly through self-ren...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2026-03-11 | PXD052344 | Pride
Although classified as hematopoietic cells, tissue-resident macrophages are selfrenewing and maintained independently of adult hematopoiesis. While most macrophages originate from embryonic precursors that seed tissues prior to birth, their exact origin is unknown. Using an in utero macrophage deple...
ORGANISM(S): Mus musculus 

Ischemic stroke recovery involves dynamic interactions between the central nervous system and infiltrating immune cells. Peripheral immune cells compete with resident microglia for spatial niches in the brain, but how modulating this balance affects recovery remains unclear. Here, we use PLX5622 ...

2025-02-20 | MTBLS12240 | MetaboLights
Blood vessel-resident macrophages safeguard blood and vessel integrity in zebrafish
Organ-specific tissue-resident macrophages dynamics during blood stage malaria
Single-cell RNA sequencing of 697 YFP+ CD64+ lamina propria macrophages isolated from Cx3cr1CreERT2.Rosa26-LSL-YFP mice 35 weeks after tamoxifen administration
ORGANISM(S): Mus musculus 
We have found the existence of two independent populations contributing to the skin-resident macrophage pool based on their different origin. We have analyzed their gene profile by deep-sequencing (RNA-Seq). Analysis of RNA-Seq data revealed a differential expression signature between both subsets o...
ORGANISM(S): Mus musculus 
DC, monocyte and macrophage networks are evolutionarily conserved but the distinct subsets have been difficult to distinguish due to shared overlapping phenotypic markers between the cells. Using transcriptome microarray profiling of human and mouse mononuclear phagocyte subsets, we have distinguish...
ORGANISM(S): Homo sapiens 
RNAseq of peritoneal macrophages from patients with non-malignent peritoneal afflictions.
ORGANISM(S): Homo sapiens 
Macrophages are essential in immune defence, tissue development and maintenance, and are involved in disease onset and progression. Their function is influenced by their microenvironment and origin. While tissue-resident macrophages originate from yolk sac progenitors and persist in some adult tissu...
ORGANISM(S): Danio rerio 
2026-03-10 | GSE296640 | GEO
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