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TranscriptomicsTranscription profiling of Dictyostelium discoideum wild type and dupA null after infection with Legionella pneumophila
The social amoeba Dictyostelium discoideum is vulnerable to infection by the pathogen that causes Legionnaire's Disease, Legionella pneumophila. Dictystelium cells lacking the dual-specificity phospahatase DupA are at least partially resistant to infection, and strikingly the expression profile of u...
ORGANISM(S): Dictyostelium discoideum 
2009-09-24 | E-TABM-509 | biostudies-arrayexpress
TranscriptomicsA Dictyostelium SH2 domain adaptor protein required for correct DIF-1 signaling and pattern formation
When developing in the light slug formation in LrrB null (lrrB-) mutants is delayed, relative to the parental strain, and the slugs are highly defective in phototaxis and thermotaxis. In the dark the mutant arrests development as an elongated mound, in a novel process we term dark stalling. The deve...
ORGANISM(S): Dictyostelium discoideum 
2011-05-31 | E-TABM-1090 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of social amoeba Dictyostelium discoideum wildtype and srfB knock-out strains detects significant differences in the expression of genes coding for proteins involved in cytoskeleton regulation and developmentally-regulated genes
Microarray analyses of genes differentially expressed in WT and srfBKO strains detected significant differences in the expression of genes coding for proteins involved in cytoskeleton regulation and in developmentally-regulated genes.
ORGANISM(S): Dictyostelium discoideum 
2008-11-03 | E-TABM-407 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Dictyostelium discoideum in response to infection with Pseudomonas aeruginosa PA01 and PA14 strains which differ in virulence
Pseudomonas aeruginosa is an opportunistic human pathogen, infecting immuno-compromised patients and causing persistent respiratory infections in people affected from cystic fibrosis. Pseudomonas strain Pseudomonas aeruginosa PA14 shows higher virulence than Pseudomonas aeruginosa PAO1 in a wide ran...
ORGANISM(S): Dictyostelium discoideum 
2008-07-09 | E-TABM-464 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Dictyostelium discoideum treated with mercury - a systems biology assessment of the model eukaryote Dictyostelium discoideum unveils compensatory responses and a critical role of the amino acid metabolic balance in the early phase of mercury induced cyto-toxicity
Gene expression alone is not able to characterize the physiological status of pollutant-challenged organisms. However, when transcriptomics is integrated with functional information, it becomes an extremely powerful tool, able to distinguish between compensatory and non-protective cytotoxic response...
ORGANISM(S): Dictyostelium discoideum 
2010-06-09 | E-TABM-710 | biostudies-arrayexpress
TranscriptomicscAR1 rescues developmental gene expression defects of rasC/rasG double mutants
It has been shown previously that rasC- cells do not aggregate, predominantly as a result of a defective cAMP relay, although there are also subtle defects in cAMP chemotaxis. There is no appreciable effect on early gene expression in response to starvation. In contrast, rasG-/rasC- cells are tota...
ORGANISM(S): Dictyostelium discoideum 
2010-10-31 | E-TABM-1085 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Dictyostelium discoides mutant cell type aspidocyte induced by heavy meatals and antibiotics
We describe the serendipitous discovery and first characterization of a new resistant cell type from Dictyostelium, which we propose to call the aspidocyte (aspida: Greek for shield). These cells are induced from amoebae by a range of toxins including heavy metals and antibiotics, and were first det...
ORGANISM(S): Dictyostelium discoideum 
2007-02-06 | E-SGRP-5 | biostudies-arrayexpress
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