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ProteomicsADAMTSL5 is an epigenetically activated oncogene conferring tumorigenic properties in hepatocellular carcinoma
The remarkable molecular heterogeneity in hepatocellular carcinoma (HCC) continues to challenge development of effective treatments and biomarkers. Here we report that the gene encoding a secreted glycoprotein, ADAMTSL5, is overexpressed and displays hypermethylated CpG islands in its gene body regi...
ORGANISM(S): Mus musculus (Mouse) 
2020-11-17 | PXD016634 | Pride
Lc-msms Hepatocellular carcinoma  oncogene  receptor tyrosine kinase  extracellular matrix  proteoglycans . Damtsl5  hepatocellular carcinoma Secretome 
TranscriptomicsHigh-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities
The ability to perturb genes in human cells is crucial for elucidating gene function and holds great potential for finding therapeutic targets for diseases such as cancer. To extend the catalog of human core and context- dependent fitness genes, we have developed a high-complexity second-generation ...
ORGANISM(S): Homo sapiens 
2015-11-25 | E-GEOD-75189 | biostudies-arrayexpress
ProteomicsTBP2/TFIIA complex drives an oocyte-type promoter usage grammar leading to female germ cell specific mRNA and endogenous retroviral element transcription
The transcriptional machinery involved in RNA polymerase II (Pol II) transcription during oogenesis is not well characterized. In somatic cells, the Pol II general transcription factor, TFIID, containing the TATA binding protein (TBP) and 13 TBP-associated factors, is the first to bind gene promoter...
ORGANISM(S): Mus musculus (Mouse) 
2020-11-16 | PXD016347 | Pride
Tbpl2 Mouse Tfiia Growing oocyte 
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