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GenomicsA role for H3K4 mono-methylation in facultative heterochromatin assembly and partitioning of chromatin readers
Mono-methylation of lysine 4 on histone H3 (H3K4me1) is a well-established feature of enhancers and promoters, although its function is unknown. Remarkably, we find H3K4me1 at the promoter regions of conditionaly-repressed muscle and stimulus-dependent inflammatory response genes in myoblasts. Durin...
ORGANISM(S): Mus musculus 
2014-03-29 | E-GEOD-50590 | biostudies-arrayexpress
UnknownHypothesizing Nutrigenomic-Based Precision Anti-Obesity Treatment and Prophylaxis: Should We Be Targeting Sarcopenia Induced Brain Dysfunction?
Not available
S-EPMC8470221 | biostudies-literature
GenomicsGenome-wide remodeling of the epigenetic landscape during myogenic differentiation
We have examined changes in the chromatin landscape during muscle differentiation by mapping the genome-wide location of ten key histone marks and transcription factors in mouse myoblasts and terminally differentiated myotubes, providing an exceptionally rich dataset that has enabled discovery of ke...
ORGANISM(S): Mus musculus 
2011-05-08 | E-GEOD-25308 | biostudies-arrayexpress
UnknownNanoparticle-Mediated Acoustic Cavitation Enables High Intensity Focused Ultrasound Ablation Without Tissue Heating.
Not available
S-EPMC6702128 | biostudies-literature
TranscriptomicsMolecular Signatures of Fetal and Adult Prostate Stem Cells
The global gene expression profiles of adult and fetal murine prostate stem cells were determined to define common and unique regulators whose misexpression might play a role in the development of prostate cancer. A distinctive core of transcriptional regulators common to both fetal and adult primit...
ORGANISM(S): Mus musculus 
2009-04-29 | E-GEOD-15580 | biostudies-arrayexpress
TranscriptomicsUGE and UGM Reveal Novel Signaling Pathways and Ligand-Receptor Interactions in the Primitive Prostate Stem Cell Niche
We isolated fetal murine urogenital sinus epithelium and urogenital sinus mesenchyme and determined their global gene expression profiles to define their differentially expressed regulators. To distinguish gene expression patterns that are shared by other developing epithelial/mesenchymal compartmen...
ORGANISM(S): Mus musculus 
2010-08-29 | E-GEOD-17797 | biostudies-arrayexpress
GenomicsGenome-wide identification of enhancers in skeletal muscle
In an effort to identify the compendium of regulatory elements that govern myogenic differentiation, we generated chromatin state maps based on the recruitment of factors (p300 and PolII) and histone modifications (H3K4me1, H3K27ac) that typify enhancers in myoblasts and myotubes. We found a remarka...
ORGANISM(S): Mus musculus 
2012-12-15 | E-GEOD-37525 | biostudies-arrayexpress
Genomics32c6825c-80c0-4d0f-9284-cc7c1a39e68a - samples
Whole transcriptome sequencing (RNA-seq) was performed on 39 PC specimens. Among them, 21 specimens also had WES data.
EGAD00001004365 | EGA
Genomicsc9d38693-41de-4186-90c3-5e52d1913254 - samples
Whole-exome sequencing (WES) was performed on a total of 34 PC specimens, with 15 cases having matched gDNAs extracted from blood.
EGAD00001004364 | EGA
GenomicsProfiling of Peritoneal Metastases from Gastric Adenocarcinoma Identified Molecular Subtypes
Peritoneal carcinomatosis (PC) occurs frequently in gastric adenocarcinoma (GAC) patients and confers poor prognosis. Multiplex profiling of primary GACs has been insightful but the underpinnings of PC’s development/progression remain largely unknown. Here we characterized exome/transcriptome/immune...
EGAS00001003180 | EGA
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