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TranscriptomicsTranscription profiling time series of human epidermal keratinocytes treated with Oncostatin-M
Cultured epidermal keratinocytes treated with OsM 1, 4, 24 & 48hrs, and Skinethic epidermal substitutes treated 1, 4, 24, 48h & 7days, each with untreated control Experiment Overall Design: Each timepoint has treated/untreated matched control. Experiment Overall Design: Skinethic 4h treated was repl...
ORGANISM(S): Homo sapiens 
2007-12-12 | E-GEOD-2822 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human epidermal keratinocytes treated with IL-1
Interleukin-1 is a proinflammatory and immunomodulatory cytokine that plays a crucial role in inflammatory diseases of the skin, including bacterial infections, bullous diseases, UV damage and especially psoriasis. To characterize the molecular effects of IL-1 in epidermis, we defined the transcript...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9120 | biostudies-arrayexpress
no omics definedTranscription profiling of human keratinocytes treated with JNK inhibitor vs. control reveals inhibition of JNK in keratinocyte cultures in vitro induces virtually all aspects of epidermal differentiation in vivo
In inflamed tissue, normal signal transduction pathways are altered by extracellular signals. For example, the JNK pathway is activated in psoriatic skin, which makes it an attractive target for treatment. To define comprehensively the JNK-regulated genes in human epidermal keratinocytes, we compare...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4828 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human epidermal keratinocytes treated with IFN-gamma reveals IFN-gamma suppressed the expression of over 100 genes responsible for cell cycle, DNA replication and RNA metabolism.
Cultured epidermal keratinocyte controls used for IFNg, TNFa and IL1 treatment. Interferon (IFN)-gamma, is a multifunctional, immunomodulatory cytokine with cell type-specific antiviral activities, particularly important in skin, where it is implicated in many diseases ranging from warts to psoriasi...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-440 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of cultured human keratinocytes treated with TNFalpha in the presence or absence of the NFkB inhibitor parthenolide
Cultured keratinocytes treated with TNFa in the presence or absence of NFkB inhibitor; time course 1, 4, 24 & 48 hrs.
ORGANISM(S): Homo sapiens 
2007-08-21 | E-GEOD-2489 | biostudies-arrayexpress
TranscriptomicsEpidermal differentiation: basal vs. suprabasal keratinocytes
In epidermal differentiation basal keratinocytes detach from the basement membrane, stop proliferating, and express a new set of structural proteins and enzymes, which results in an impermeable protein/lipid barrier that protects us. To define the transcriptional changes essential for this process, ...
ORGANISM(S): Homo sapiens 
2010-12-15 | E-GEOD-26059 | biostudies-arrayexpress
TranscriptomicsTranscriptional Profiling Defines the Roles of ERK and p38 Kinases in Epidermal Keratinocytes
Epidermal keratinocytes respond to extracellular influences by activating cytoplasmic signal transduction pathways that change the transcriptional profiles of affected cells. To define responses to two such pathways, p38 and ERK, we used SB203580 and PD98059 as specific inhibitors, and identified th...
ORGANISM(S): Homo sapiens 
2013-09-05 | E-GEOD-50591 | biostudies-arrayexpress
TranscriptomicsTRANSCRIPTIONAL EFFECTS OF INHIBITING EGFR IN KERATINOCYTES
EGFR activation is important in human epithelial malignancies, including cutaneous squamous cell carcinoma, lung, colon, pancreatic and other cancers. Therapies targeting EGFR are currently used to treat such cancers, but one significant drawback to EGFR inhibitor therapies is the associated skin to...
ORGANISM(S): Homo sapiens 
2012-10-19 | E-GEOD-41680 | biostudies-arrayexpress
TranscriptomicsEffects of Glucocorticoids in Epidermal Keratinocytes
Glucocorticoids (GCs) have a long history of use as therapeutic agents for numerous skin diseases. Surprisingly, their specific molecular effects are largely unknown. To characterize GC action in epidermis, we compared the transcriptional profiles of primary human keratinocytes untreated and treated...
ORGANISM(S): Homo sapiens 
2011-01-07 | E-GEOD-26487 | biostudies-arrayexpress
TranscriptomicsHuman epidermal keratinocytes treated with retinoic acid or thyroid hormone
Targets of Retinoic Acid (RA) were identified in primary human epidermal keratinocytes grown in the presence or absence of all-trans retinoic acid for 1, 4, 24, 48 and 72 hours. Targets of Thyroid Hormone (T3) were identified in primary human epidermal keratinocytes grown in the presence or absenc...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-22298 | biostudies-arrayexpress
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