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UnknownGermline NPM1 mutations lead to altered rRNA 2'-O-methylation and cause dyskeratosis congenita.
Not available
S-EPMC6858547 | biostudies-literature
TranscriptomicsIGR_MEGACARYOCYTES_STUDY_OB
The molecular bases of cellular changes that occur during ontogeny of human megakaryopoiesis remained unknown. We performed global gene expression profiling of pure populations of megakaryocytes (MK) derived from ES cells (MKES), fetal liver (MKFL), cord blood (MKCB) and adult blood (MKAD). A close ...
ORGANISM(S): Homo sapiens 
2013-06-24 | E-MTAB-1452 | biostudies-arrayexpress
Unknownp19 INK4d controls hematopoietic stem cells in a cell-autonomous manner during genotoxic stress and through the microenvironment during aging.
Not available
S-EPMC4264042 | biostudies-literature
UnknownMDM4 overexpression alleviates developmental and hematopoietic defects in Fancg deficient mice.
Not available
S-EPMC12463665 | biostudies-literature
TranscriptomicsIGR_MEGAKARYOCYTE_STUDY_TM
The OTT1-MAL fusion oncogene is specifically associated with human infant acute megakaryoblastic leukemia. In a murine model of OTT-MAL expression, leukemic cells expressing OTT-MAL present an aberrant activation of the Notch pathway target genes. IKZF1 was proposed to interact with the Notch signal...
ORGANISM(S): Mus musculus 
2013-08-08 | E-MTAB-897 | biostudies-arrayexpress
UnknownIkaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling.
Not available
S-EPMC3612856 | biostudies-literature
UnknownAPOE Molecular Spectrum in a French Cohort with Primary Dyslipidemia.
Not available
S-EPMC9145810 | biostudies-literature
TranscriptomicsRNAi knock-down of MKL1 in human megakaryocytes derived from cord blood or cytapheresis
Characterize the genes regulated by MKL1/SRF complex in human megakaryocytes (MKs) derived from cord blood or cytapheresis : Using a knock down approach by small interference of MKL1 in MK progenitors, we observed a decrease in the percentage of cells with actin polymerization after adhesion on vari...
ORGANISM(S): Homo sapiens 
2009-09-14 | E-TABM-640 | biostudies-arrayexpress
UnknownLevel of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia.
Not available
S-EPMC4347283 | biostudies-literature
TranscriptomicsTranscription profiling by array of the effect of S78454, a pan histone deacetylase inhibitor, on megakaryopoiesis derived from human CD34+ cells
S78454 (Abexinostat, PCI-24781) is a pan histone deacetylase inhibitor (HDACi) that demonstrates efficacy in malignancy treatment. Like other HDACi, this drug induces a profound thrombocytopenia, whose mechanism is partially understood. We have tested its effect at doses reached in patients plasma o...
ORGANISM(S): Homo sapiens 
2013-06-30 | E-MTAB-1180 | biostudies-arrayexpress
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