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TranscriptomicsTranscription profiling of brain and gut neurospheres of wild type and Bmi-1 knockout mice to reveal that Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation.
The cRNA derived from Brain and Gut neurospheres of wild type and BMI-1 knockout mice were hybridized to Affymetrix mouse ver 2 Chips A, B and C. In case of brain neurospheres, the cRNA were generated by one round RNA amplification (conventional method). In contrast, the cRNA of Gut neurospheres wer...
ORGANISM(S): Mus musculus 
2007-12-15 | E-GEOD-611 | biostudies-arrayexpress
ProteomicsPLASMA PROTEOMIC ANALYSIS OF RARE BMI-DISCORDANT MONOZYGOTIC TWIN PAIRS
The aim of the current study is to establish the effect of excess body wiehgt and liver fat on plasma proteomic profile without interference from genetic variation. Label-free proteomics (HDMSE) was performed on plasma samples of young healthy monozygotic twins who were discordant for BMI. the twins...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084372 | MassIVE
TranscriptomicsshRNA-mediated knock down of Bmi-1 and Mel-18 in medulloblastoma cells
Bmi-1 and Mel-18 are close structural homologues that belong to the polycomb group (PcG) of transcriptional regulators of homeotic gene expression in development. They are believed to stably maintain repression of gene expression by altering the state of chromatin at specific promoters. A number of...
ORGANISM(S): Homo sapiens 
2007-10-31 | E-GEOD-7578 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human breast tumors and adjacent cancer-free tissue to study Bmi-1 and Mel-18 expression
A total of 79 breast tumors (71 malignant tumors, 6 fibroadenomas, and 2 DCIS) were studied and compared to the reduction mammoplastic specimens of 12 healthy women as well as adjacent cancer-free tissue for 23 of the malignant tumors. Polycomb Group (PcG) proteins Bmi-1 and Mel-18 were then studied...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-MTAB-271 | biostudies-arrayexpress
GenomicsBrucella microti strain:HUN-Bmi-01
Brucella microti HUN-Bmi-01 genome sequencing
PRJNA272528 | ENA
TranscriptomicsBmi-regulated miRNA expression pattern in head and neck cancers
The critical role of Bmi1 in promoting stem cell properties has been shown in different type of human cancers. Here, we established four stable clones to study Bmi-regulated miRNA expression patterns in head and neck caners. Bmi1-overexpressing cell lines (FaDu- Bmi1vs. FaDu-pcDNA3 cell line), and k...
ORGANISM(S): Homo sapiens 
2013-02-11 | E-GEOD-31910 | biostudies-arrayexpress
TranscriptomicsThe Polycomb Group Protein Bmi-1 is essential for the growth of Multiple Myeloma cells
The RPMI-8226 human multiple myeloma cell line was stably infected with either a validated shRNA against BMI1 or a control shRNA. RNA was prepared from these lines, +/- doxycycline induction and at various time points post-induction. Samples were hybridized on the Affymetrix U133plus2 human genome...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-21912 | biostudies-arrayexpress
TranscriptomicsComparision of Bmi-1, Ring1B, H3K27me3, Ser2 Pol II, Ser 5 Pol II binding on Hox and non-Hox genes
Bmi-1, Ring1B, H3K27me3, Ser2 Pol II, Ser 5 Pol II binding pattern in WT and Psip1 KO MEFs Menin occupancy is studied over Hox genes and several non-hox genes Bmi-1, Ring1B, H3K27me3, Ser2 Pol II, Ser 5 Pol II ChIPs from WT and Psip1 KO MEFs
ORGANISM(S): Mus musculus 
2014-06-27 | E-GEOD-49181 | biostudies-arrayexpress
ProteomicsHuman obesity associated circulating sEVs proteomics
This clinical study was approved by the Ethics Committee at Hangzhou Xixi Hospital (Zhejiang province, China). A total of 11 males and 37 females were included in normal weight healthy control group (NC); 77 males and 19 females were included in BMI group. Normal weight healthy control group: BMI eq...
ORGANISM(S): Homo sapiens (Human) 
2024-02-27 | PXD041236 | Pride
Human  obesity  bmi  plasma  exosome  proteomics 
ProteomicsCross-sectional association of salivary proteins with age, sex, body mass index, smoking, and education
In a cross-sectional approach, we analyzed the influence of age, sex, body mass index (BMI), smoking, and education on salivary protein signatures in whole saliva samples of 187 individuals. Subjects were randomly selected from the population-based Study of Health in Pomerania (SHIP-Trend).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-03-13 | MSV000083569 | MassIVE
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