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MetabolomicsPRODH regultes naive pluripotency by influencing mitochondrial oxidative phosphorylation (Targeted metabolomics)

Naïve human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood. Here we report that, proline dehydrogenase (PRODH), a mitochondria-local...

2024-02-12 | MTBLS7832 | MetaboLights
MetabolomicsPRODH regultes naive pluripotency by influencing mitochondrial oxidative phosphorylation (Untargeted metabolomics)

Naïve human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood. Here we report that, proline dehydrogenase (PRODH), a mitochondria-local...

2024-02-12 | MTBLS7840 | MetaboLights
MetabolomicsMulti-omics insights into high-carotenoid hybrid potato lines: enhanced nutritional quality and metabolic regulation for food applications

Modern potato varieties often exhibit low carotenoid content, limiting their nutritional value and processing performance. This study employed a multi-omics approach (physicochemical analysis, metabolomics, mineral profiling, transcriptomics, and microbiome sequencing) to investigate the molecula...

2025-11-12 | MTBLS13298 | MetaboLights
MetabolomicsExogenous L-Alanine promotes phagocytosis multidrug-resistant bacterial pathogens (V. parahaemolyticus-infected spleen metabolomics)

Multidrug-resistant bacteria present a major threat to public health. Therefore, new drugs or approaches are urgently needed to manage and mitigate this threat. Here, we screen the molecular candidates that allow the survival of mice upon Vibrio parahaemolyticus infection by integrated p...

2024-09-26 | MTBLS7996 | MetaboLights
UnknownThe Identification and Characterization of the <i>PeGRF</i> Gene Family in <i>Populus euphratica</i> Oliv. Heteromorphic Leaves Provide a Theoretical Basis for the Functional Study of <i>PeGRF9</i>.
Not available
S-EPMC11720670 | biostudies-literature
UnknownIsopropoxy Tetramethyl Dioxaborolane on TiO2: Reaction Pathway and Formation of a Visible-Light-Sensitive Photocatalyst.
Not available
S-EPMC6854563 | biostudies-literature
TranscriptomicsTranscriptional profiles of Salmonella typhimurium wt, hfq and smpB mutants in four different growth conditions
S. typhimurium 14028 wt, hfq and smpB were harvested from log phase LB (LBlog); (2), stationary phase LB (LBstat); (3) 4h MgM medium pH 5.0 after resuspension of LB stat culture (MgMshock); and (4) log phase MgM medium pH5.0 after 100fold dilution of an LB stat culture (MgMDil). Total RNA was extrac...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2008-12-12 | E-GEOD-11486 | biostudies-arrayexpress
UnknownAccelerated Development of Novel Biomass-Based Polyurethane Adhesives via Machine Learning.
Not available
S-EPMC11912195 | biostudies-literature
TranscriptomicsRNA-seq analysis of flg22-induced gene expression changes in wild type, asr3-1 mutant and OX9 overexpression line
The correlation coefficient (R) for the expression profile of all transcripts between WT and asr3-1, and between WT and OX9 without flg22 treatment is close to linear, suggesting that ASR3 does not affect general gene transcription. Hierarchical clustering analysis flg22-induced genes in any of the ...
ORGANISM(S): Arabidopsis thaliana 
2015-08-26 | E-GEOD-63603 | biostudies-arrayexpress
UnknownSARDH in the 1-C metabolism sculpts the T-cell fate and serves as a potential cancer therapeutic target.
Not available
S-EPMC12575850 | biostudies-literature
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