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Motivation: Including ion mobility separation (IMS) into mass spectrometry proteomics experiments is useful to improve coverage and throughput. Many IMS devices enable linking experimentally derived mobility of an ion to its collisional cross-section (CCS), a highly reproducible physicochemical pro...
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse) 
Snakes possess a unique sensory system for detecting infrared radiation, enabling them to generate a ‘thermal image’ of predators or prey. Infrared signals are initially received by the pit organ, a highly specialized facial structure that is innervated by nerve fibers of the somatosensory system. H...
ORGANISM(S): Pantherophis obsoletus lindheimeri 
A genome-wide CRISPR-Cas9 knockout screen was performed in the breast cancer cell lines T47D, MCF7, and CAMA-1 to identify genes modulating sensitivity and resistance to capivasertib, a selective AKT inhibitor. Cells were transduced with a CRISPR library, followed by treatment with capivasertib or v...
ORGANISM(S): Homo sapiens 
Aging is a major risk factor for cardiovascular diseases, yet the contribution of the lymphatic vasculature to cardiac aging remains largely unexplored. Here, we show that aging reduces lymphatic vessel density in human and mice hearts and induces morphological changes, including the formation of zi...
ORGANISM(S): Mus musculus 
A dataset containing dried blood spots from human blood used as quality control samples to monitor variation, used as technical replicates (TR), digestion replicates (DR) and HeLa samples. Dried blood spots are blood from a finger prick spotted onto Whatman cards and dried. An aliquot of pooled, mix...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
A dataset containing native plasma samples used as quality control digestion replicates. Samples were automatically processed on i7 automated liquid handling system (Beckman Coulter). Briefly, proteins were extracted and denatured with a buffer composed of TFE (2,2,2-Trifluoroethanol), DTT and ammon...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
A dataset containing whole blood samples used as quality control digestion replicates. Samples were automatically processed on i7 automated liquid handling system (Beckman Coulter). Briefly, proteins were extracted and denatured with a buffer composed of TFE (2,2,2-Trifluoroethanol), DTT and ammoniu...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
A dataset containing depleted plasma samples used as quality control technical replicates (TR) and digestion replicates (DR). Plasma aliquot was shunted to Top14 Abundant Protein Depletion Resin (A36372) based depletion. Depleted plasma samples were processed on a i7 automated liquid handling system...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
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