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Chronic lymphocytic leukemia (CLL) is characterized by substantial clinical heterogeneity, despite relatively few genetic alterations. To provide a basis for studying epigenome deregulation in CLL, we established genome-wide chromatin accessibility maps for 88 CLL samples from 55 patients using the ...
ORGANISM(S): Homo sapiens 
In our study we applied a genome-wide DNA methylation analysis approach, MethylCap-seq, to map the differentially methylated regions in 24 tumor and matched normal colon samples. In total, 2687 frequently hypermethylated and 468 frequently hypomethylated regions were identified, which include potent...
ORGANISM(S): Homo sapiens 
The aim was to study the effects of hypoxia and differential gene expression on two different genotypes (wildtype (WT) and the transgenic SAG12:ipt (T5)) through the use of a controlled air feed.
ORGANISM(S): Arabidopsis thaliana 
Tlx expression is upregulated after stroke, and stroke-induced neurogenesis is blocked when Tlx is inactivated. Tlx overexpression in NSCs leads to massive induction of neurogenesis via stroke, which leads to an improved motor function recovery. Four Tlx overexpressing mice, and 5 wild type mice as...
ORGANISM(S): Mus musculus 
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