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TranscriptomicsCentrosome amplification is sufficient to promote spontaneous tumorigenesis in mammals
Centrosome amplification is a common feature of human tumors, but whether this is a cause or a consequence of human cancer remains unclear. Here, we report the creation of a mouse model in which centrosome number can be persistently increased in the absence of additional genetic defects. We show tha...
ORGANISM(S): Mus musculus 
2017-02-04 | E-MTAB-5043 | biostudies-arrayexpress
TranscriptomicsGenomic landscape of carcinogen induced mouse skin squamous cell carcinoma: whole-genome sequencing
Low coverage whole-genome sequencing of induced murine squamous cell carcinoma. 17 samples are included.
ORGANISM(S): Mus musculus 
2015-04-10 | E-MTAB-2888 | biostudies-arrayexpress
TranscriptomicsGenomic landscape of carcinogen induced mouse skin squamous cell carcinoma: RNA-sequencing
RNA-sequencing of induced murine squamous cell carcinoma.
ORGANISM(S): Mus musculus 
2015-04-16 | E-MTAB-2889 | biostudies-arrayexpress
GenomicsGenomic landscape of carcinogen induced mouse skin squamous cell carcinoma: whole-exome sequencing
Whole-exome sequencing of induced murine squamous cell carcinoma. 26 samples are included.
ORGANISM(S): Mus musculus 
2014-09-11 | E-MTAB-2887 | biostudies-arrayexpress
TranscriptomicsExpression profiling of budding cells in colorectal cancer suggests an EMT-like phenotype and molecular subtype switching
Tumour buds undergo phenotype switching while detaching from the main tumour, as they acquire more migratory characteristics and tend to stop proliferating. Simultaneously, an EMT-like signature is observed in the tumour buds under the form of active WNT, TGF and receptor tyrosine kinase signalling....
ORGANISM(S): Homo sapiens 
2017-02-04 | E-MTAB-4065 | biostudies-arrayexpress
TranscriptomicsSingle cell sequencing of lung carcinoma
Single cell sequencing of 5 dissected lung tumors.
ORGANISM(S): Homo sapiens 
2018-07-09 | E-MTAB-6149 | biostudies-arrayexpress
GenomicsEpigenetic regulation and transcriptional repression by Tet1 in the early post-implantation mouse embryo: ChIP seq
The mammalian TET dioxygenases contribute to global waves of DNA demethylation in the zygote and in primordial germ cells, but their involvement during de novo DNA methylation at peri/post-implantation development is unknown. Here, we show novel physiological functions of Tet1 in the pre-primitive s...
ORGANISM(S): Mus musculus 
2017-05-15 | E-MTAB-5562 | biostudies-arrayexpress
GenomicsCentrosome amplification triggers tumorigenesis in p53 deficient epidermis
While aneuploidy is found in more than 90% of solid tumors, it is unclear whether aneuploidy is the cause or the consequence of tumorigenesis. Different mouse models deficient in centrosomal or spindle checkpoint proteins that induce aneuploidy show either a promotion or a decrease in tumorigenesis ...
ORGANISM(S): Mus musculus 
2015-10-27 | E-MTAB-3733 | biostudies-arrayexpress
TranscriptomicsSingle cell sequencing of 3 lung carcinomas
Single cell sequencing of 3 lung tumours. 3 malignant tumor parts were sequenced for each tumor
ORGANISM(S): Homo sapiens 
2018-08-18 | E-MTAB-6653 | biostudies-arrayexpress
TranscriptomicsAmplification of 1q32.1 refines the molecular classification of endometrial carcinoma: SNP array
The experiment aimed at refining the classification of endometrial cancer by profiling somatic copy number aberrations (SCNAs). SCNAs affecting chromosome 1q32.1 significantly correlated with worse survival and functional validation of a plausible oncogene showed MDM4 as an oncogenic driver in 1q32....
ORGANISM(S): Homo sapiens 
2019-07-27 | E-MTAB-5908 | biostudies-arrayexpress
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