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GenomicsPhyloepigenetic comparison of apes
We have determined methylation state differences in the epigenomes of neutrophils purified from human and chimpanzee. We used deep sequencing of ends generated by digestion with a methylation-sensitive restriction enzyme, followed by analysis with the MetMap computational pipeline to infer methylati...
ORGANISM(S): Pongo pygmaeus 
2011-09-09 | E-GEOD-22376 | biostudies-arrayexpress
TranscriptomicsDeep sequencing and functional annotation reveal miRNAs implicated in the cell senescence phenotype
In cell senescence, cultured cells cease proliferating and acquire aberrant gene expression patterns. MicroRNAs (miRNAs) modulate gene expression through translational repression or mRNA degradation, and have been implicated in senescence. We have used deep sequencing to carry out a comprehensive su...
ORGANISM(S): Homo sapiens 
2011-08-09 | E-GEOD-27404 | biostudies-arrayexpress
GenomicsThe methylome of Drosophila melanogaster
Cytosine methylation in the genome of Drosophila melanogaster has been elusive and controversial: methylcytosine has been detected at very low levels in early embryos, but the genomic location and function of methylation has not been established. We have mapped cytosine methylation genomewide in St...
ORGANISM(S): Drosophila melanogaster 
2014-02-18 | E-GEOD-34425 | biostudies-arrayexpress
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