Sort   by:  
 Page size 
TranscriptomicsLongitudinal expression data from CD8+ T cells responding to LCMV-Armstrong or LCMV-Clone 13
During acute viral infections, naïve CD8+ T cells differentiate into effector CD8+ T cells and, after viral control, into memory CD8+ T cells. Memory CD8+ T cells are highly functional, proliferate rapidly upon reinfection and persist long-term without antigen. In contrast, during chronic infections...
ORGANISM(S): Mus musculus 
2012-11-23 | E-GEOD-41867 | biostudies-arrayexpress
TranscriptomicsMurine CD8+ T cells: in vitro-derived vs. thymocytes
Transcriptional profiling of mouse in-vitro derived CD8+ cells (obtained after culturing BM-HSCs isolated from B6 mice) with OP9-DL1 cells for 35 days were compared to CD8+ thymocytes isolated from 4-5 weeks old B6 mice. Our goal was to determine similarities and differences in gene expression prof...
ORGANISM(S): Mus musculus 
2012-09-05 | E-GEOD-37669 | biostudies-arrayexpress
TranscriptomicsExpression data from Tcf1-expressing Thy1+CD25+ T lineage cells
We used microarrays to perform a global gene expression analysis in Tcf1-expressing Thy1+CD25+ T lineage cells that develop on OP9 stroma in the absence of Notch1 signals. We compare this to the starting population, LMPP progenitors, and to control expressing T lineage cells that developed on OP9 st...
ORGANISM(S): Mus musculus 
2011-08-03 | E-GEOD-26560 | biostudies-arrayexpress
TranscriptomicsMolecular signature of CD8+ T cell exhaustion in metastases but not in peripheral blood from melanoma patients
In chronic viral infections such as HIV-1, HBV and HCV, CD8+ T cells may become M-bM-^@M-^]exhaustedM-bM-^@M-^], characterized by progressive functional deficiency. Recently, the underlying mechanisms have been characterized by molecular profiling of virus-specific CD8+ T cells. In contrast, only li...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-24536 | biostudies-arrayexpress
TranscriptomicsExpression data from Tcf1 deficient and Tcf1 wildtype cultured bone marrow lymphoid primed progenitors after four days on Notch ligand expressing stroma (OP9-DL4).
Tcf1 is necessary for optimal T lineage development. Tcf1 deficient progenitors fail to initiate the T lineage program in vitro and development is severely defective in vivo. We used microarrays to assess the overal global gene expression differences from Tcf1 wildtype and deficient lymphoid biased ...
ORGANISM(S): Mus musculus 
2011-08-03 | E-GEOD-26559 | biostudies-arrayexpress
TranscriptomicsExpression profiling of immortalized mature, murine T cells
The RNA expression profile of retrovirally immortalized mature, murine T cells was compared to the expression profile of mature naive, murine T lymphocytes and/or murine thymocytes of healthy C57BL/6 mice. Retroviral insertional mutagenesis can contribute to immortalization of mature T lymphocytes, ...
ORGANISM(S): Mus musculus 
2011-07-01 | E-GEOD-30349 | biostudies-arrayexpress
TranscriptomicsLongitudinal expression data from CD4+ T cells responding to LCMV-Armstrong or LCMV-Clone 13
During acute viral infections, naïve CD4+ T cells differentiate into effector CD4+ T cells and, after viral control, into memory CD4+ T cells. Memory CD4+ T cells are highly functional, proliferate rapidly upon reinfection and persist long-term without antigen. In contrast, during chronic infections...
ORGANISM(S): Mus musculus 
2014-10-24 | E-GEOD-41866 | biostudies-arrayexpress
TranscriptomicsIdentification of direct T-box target genes in the developing zebrafish mesoderm
The zebrafish genes spadetail (spt) and no tail (ntl) encode T-box transcription factors that are important for early mesoderm development. Although much has been done to characterize these genes, the identity and location of target regulatory elements remain largely unknown. Here, we survey the gen...
ORGANISM(S): Danio rerio 
2010-05-19 | E-GEOD-12857 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human T cell lines isolated from tumor infiltrating lymphocytes or peripheral blood lymphocytes of a patient with large cell carcinoma of the lung
The IGR-Heu tumor cell line was established from patient Heu suffering from large cell carcinoma of the lung. Heu171, Heu127 and Heu161 T cell clones were isolated from autologous tumor infiltrating lymphocytes. H32 T cell line and H32-22 clone were isolated from autologous PBL after stimulation wit...
ORGANISM(S): Homo sapiens 
2007-03-02 | E-TABM-208 | biostudies-arrayexpress
TranscriptomicsExpression data from wild-type and microRNA-155 (miR-155) deficient CD8 T cells
MicroRNA-155 (miR-155) is upregulated in primary effector CD8 T cells but is expressed at low amounts in naïve cells. Anti-viral CD8 T cell responses and viral clearance were impaired in miR-155 deficient (bic-/-) mice, and this defect was intrinsic to CD8 T cells, as adoptively transferred bic-/- ...
ORGANISM(S): Mus musculus 
2013-02-26 | E-GEOD-44649 | biostudies-arrayexpress
Sort   by:  
 Page size