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ProteomicsA Bacteroides fragilis protease activates host PAR2 to induce intestinal pain and inflammation
Protease-activated receptor 2 (PAR2) is a central regulator of intestinal barrier function, inflammation and pain. Upregulated intestinal proteolysis and PAR2-signaling are implicated in inflammatory bowel diseases (IBDs) and irritable bowel syndrome (IBS), conditions often associated with gut micro...
ORGANISM(S): Bacteroides fragilis (strain ATCC 25285 / NCTC 9343) 
2025-09-28 | PXD059166 | Pride
Chemical proteomics Activity-based protein profiiling Bacteroides fragilis 
ProteomicsChemoproteomic identification of a dipeptidyl peptidase 4 (DPP4) homolog in Bacteroides thetaiotaomicron important for envelope integrity and fitness
Serine hydrolases play important roles in signaling and human metabolism, yet little is known about the functions of these enzymes in gut commensal bacteria. Using bioinformatics and chemoproteomics, we identify serine hydrolases in the gut commensal Bacteroides thetaiotaomicron that are specific to...
ORGANISM(S): Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) 
2023-07-10 | PXD035963 | Pride
Activity-based protein profiling Protease Microbiome 
ProteomicsHewings et al. 2018
raw data files associated with manuscript titled "Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes". Result file includes all PSMs identified in the experiment after performing necessary quality filter.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-01-25 | MSV000081972 | MassIVE
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