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UnknownIdentification of a 24-gene prognostic signature that improves the European LeukemiaNet risk classification of acute myeloid leukemia: an international collaborative study.
Not available
S-EPMC3595425 | biostudies-literature
UnknownSequential high-dose cytarabine and mitoxantrone (S-HAM) versus standard double induction in acute myeloid leukemia-a phase 3 study.
Not available
S-EPMC6286323 | biostudies-literature
TranscriptomicsExpression analysis of genes located in the minimally deleted regions of 13q14 and 11q22-23 in chronic lymphocytic leukemia – unexpected expression pattern of the RHO GTPase activator ARHGAP20
In chronic lymphocytic leukemia (CLL), 13q14 and 11q22-23 deletions are found in 2/3 of the cases. 11q22-23 deletions are associated with poor survival, whereas 13q14 deletions as single abnormality are often found in indolent disease forms. The molecular basis for this difference in prognosis is no...
ORGANISM(S): Homo sapiens 
2011-10-13 | E-GEOD-25571 | biostudies-arrayexpress
TranscriptomicsIdentification of a Potently Oncogenic CALM-AF10 Minimal-Fusion Mutant (miRNA)
The t(10;11) p (13;q14) translocation, giving rise to CALM-AF10, is a recurring chromosomal translocation observed in several types of acute leukemias as well as in lymphoma. We have previously demonstrated that the expression of the human CALM/AF10 fusion gene in murine bone marrow stem and progeni...
ORGANISM(S): Mus musculus 
2011-10-04 | E-GEOD-27512 | biostudies-arrayexpress
TranscriptomicsIdentification of a Potently Oncogenic CALM-AF10 Minimal-Fusion Mutant (mRNA)
The t(10;11) p (13;q14) translocation, giving rise to CALM-AF10, is a recurring chromosomal translocation observed in several types of acute leukemias as well as in lymphoma. We have previously demonstrated that the expression of the human CALM/AF10 fusion gene in murine bone marrow stem and progeni...
ORGANISM(S): Mus musculus 
2011-10-04 | E-GEOD-27513 | biostudies-arrayexpress
UnknownAcute myeloid leukemia driven by the CALM-AF10 fusion gene is dependent on BMI1.
Not available
S-EPMC10586237 | biostudies-literature
UnknownGenetic heterogeneity of cytogenetically normal AML with mutations of CEBPA.
Not available
S-EPMC6199648 | biostudies-literature
UnknownA mutation in the 5'-UTR of IFITM5 creates an in-frame start codon and causes autosomal-dominant osteogenesis imperfecta type V with hyperplastic callus.
Not available
S-EPMC3415541 | biostudies-literature
UnknownRelapse of acute myeloid leukemia after allogeneic stem cell transplantation is associated with gain of WT1 alterations and high mutation load.
Not available
S-EPMC6269290 | biostudies-literature
ProteomicsGenome-Wide CRISPR-Cas9 Screening Identifies a Synergy between Hypomethylating Agents and SUMOylation Blockade in Myelodysplastic Syndromes and Acute Myeloid Leukemia
Hypomethylating agents (HMAs) are frontline therapies effective at altering the natural course of Myelodysplastic Neoplasms (MDS). However, acquired resistance and treatment failure are hallmarks of HMA therapy. Developing effective and rational HMA-focused combinatorial therapies is challenging as...
ORGANISM(S): Homo sapiens (Human) 
2024-07-25 | PXD050539 | Pride
Myelodysplastic neoplasms Proteomics Genome-wide crispr-cas9 screen Sumo 
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