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TranscriptomicsNOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation
Breast cancer is genetically heterogeneous, and recent studies have underlined a prominent contribution of epigenetics to the development of this disease. To uncover new synthetic lethalities with known breast cancer oncogenes, we screened an epigenome-focused short hairpin RNA library on a panel...
ORGANISM(S): Homo sapiens 
2014-11-21 | E-GEOD-61727 | biostudies-arrayexpress
UnknownDeletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations.
Not available
S-EPMC5376749 | biostudies-literature
UnknownAcquired nintedanib resistance in FGFR1-driven small cell lung cancer: role of endothelin-A receptor-activated ABCB1 expression.
Not available
S-EPMC5226575 | biostudies-literature
ProteomicsSystematic characterization of BAF mutations explains intra-complex synthetic lethalities
Aberrations in genes coding for subunits of the BAF chromatin remodeling complex are highly abundant in human cancers. Currently, it is not understood how these loss-of-function mutations contribute to cancer development and how they can be targeted therapeutically. The cancer type specific occurren...
ORGANISM(S): Homo sapiens (Human) 
2019-08-01 | PXD013102 | Pride
Atac-seq Interaction proteomics Chromatin remodeling Baf complex Chromatin accessibility Chromatin binding Transcriptomics Synthetic lethality Mammalian swi/snf complex 
UnknownA strand-specific switch in noncoding transcription switches the function of a Polycomb/Trithorax response element.
Not available
S-EPMC4270207 | biostudies-literature
UnknownSystematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers.
Not available
S-EPMC6952272 | biostudies-literature
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