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TranscriptomicsExpression data from human fibroblasts 6 and 12 hours after 8-oxoguanine treatment
8-oxoguanine is excised from DNA by 8-oxoguanine DNA glycosylase-1 during DNA base excision repair. We used microarrays to gain insight into the potential biological function of the excised, free 8-oxoguanine base. MRC5, human diploid fibroblasts were exposed to 8-oxoguanine and changes in gene expr...
ORGANISM(S): Homo sapiens 
2011-01-27 | E-GEOD-26813 | biostudies-arrayexpress
TranscriptomicsReal-time quantitative PCR analysis of mouse lungs
Balb/cJ mouse received control RNAi or RNAi to 8-oxoguanine DNA glycosylase (Ogg1) intranasally prior to the exposure for 1 h to a) glucose oxidase (1 mU) to induce OGG1-BER or b) OGG1-BER product 8-oxoguanine (1 M-NM-
ORGANISM(S): Mus musculus 
2014-08-26 | E-GEOD-60711 | biostudies-arrayexpress
Transcriptomics8-Oxoguanine DNA glycosylase-1 DNA repair-signaling induces gene expression associated to airway remodeling
Purpose: The aim of this study is to test whether global gene expression induced by multiple challenges with OGG1-BER product 8-oxoG in mouse airways is linked to airway remodeling. Methods: RNAs extracted from individual mouse lungs (experimental group: n=5) were pooled and a total 1 ?g RNA was use...
ORGANISM(S): Mus musculus 
2015-07-03 | E-GEOD-65031 | biostudies-arrayexpress
TranscriptomicsOGG1-initiated DNA base excision repair is linked to inflammatory gene expression and lung inflammation
Purpose: The aim of this study is to evaluate the global gene expression induced by OGG1-BER product 8-oxoG in mouse airways. Methods: RNA extracted from individual mouse lungs (experimental group: n=5) were pooled and a total 1 M-NM-
ORGANISM(S): Mus musculus 
2015-02-02 | E-GEOD-61095 | biostudies-arrayexpress
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