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UnknownHigh-resolution iron X-ray absorption spectroscopic and computational studies of non-heme diiron peroxo intermediates.
Ferritin-like carboxylate-bridged non-heme diiron enzymes activate O2 for a variety of difficult reactions throughout nature. These reactions often begin by abstraction of hydrogen from strong CH bonds. The enzymes activate O2 at their diferrous cofactors to form canonical dife...
S-EPMC7012765 | biostudies-literature
UnknownSARS-CoV-2 N gene dropout and N gene Ct value shift as indicator for the presence of B.1.1.7 lineage in a commercial multiplex PCR assay.

Objectives

Detection and surveillance of SARS-CoV-2 is of eminent importance, particularly due to the rapid emergence of variants of concern (VOCs). In this study we evaluated if a commercially available quantitative real-time PCR (qRT-PCR) assay can identify SARS-CoV-2 B.1.1.7 lineage sampl...
S-EPMC8142743 | biostudies-literature
UnknownLeishmania disease development depends on the presence of apoptotic promastigotes in the virulent inoculum.
The obligate intracellular pathogen Leishmania major survives and multiplies in professional phagocytes. The evasion strategy to circumvent killing by host phagocytes and establish a productive infection is poorly understood. Here we report that the virulent inoculum of Leishmania promastigotes cont...
S-EPMC1564231 | biostudies-literature
UnknownReal-World Effectiveness of Remdesivir in Adults Hospitalized With Coronavirus Disease 2019 (COVID-19): A Retrospective, Multicenter Comparative Effectiveness Study.

Background

There is an urgent need to understand the real-world effectiveness of remdesivir in the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Methods

This was a retrospective comparative effectiveness study. Individuals hospitalized in a large private h...
S-EPMC8754724 | biostudies-literature
UnknownMoving away from the "unit cost". Predicting country-specific average cost curves of VMMC services accounting for variations in service delivery platforms in sub-Saharan Africa.

Background

One critical element to optimize funding decisions involves the cost and efficiency implications of implementing alternative program components and configurations. Program planners, policy makers and funders alike are in need of relevant, strategic data and analyses to help them p...
S-EPMC8062035 | biostudies-literature
UnknownRegional Nodal Irradiation in Early-Stage Breast Cancer.

Background

Most women with breast cancer who undergo breast-conserving surgery receive whole-breast irradiation. We examined whether the addition of regional nodal irradiation to whole-breast irradiation improved outcomes.

Methods

We randomly assigned women with node-positive or high-...
S-EPMC4556358 | biostudies-literature
UnknownPrevention of HIV-1 infection with early antiretroviral therapy.

Background

Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples.

Methods

In nine countries, we enrolled 1763 couples in which one partner was HIV-1-positive and the other was HIV-1-n...
S-EPMC3200068 | biostudies-literature
UnknownAntiretroviral Therapy for the Prevention of HIV-1 Transmission.

Background

An interim analysis of data from the HIV Prevention Trials Network (HPTN) 052 trial showed that antiretroviral therapy (ART) prevented more than 96% of genetically linked infections caused by human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples. ART was then offer...
S-EPMC5049503 | biostudies-literature
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