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TranscriptomicsTranscription profiling of rat proximal femoral growthplate after mid-shaft fracture
Mid-shaft fracture stimulates bone lengthening by increasing linear growth at the growthplate. This project studied changes in mRNA in the proximal growthplate after a mid-shaft fracture in a rat model. Experiment Overall Design: Study of rat proximal femoral growthplate after mid-shaft fracture in...
ORGANISM(S): Rattus norvegicus 
2008-06-12 | E-GEOD-3298 | biostudies-arrayexpress
TranscriptomicsmiRNA expression data from callus in standard fracture healing models and from fibrous tissues in nonunion models in rats on post-fracture day 14
Profiling of miRNA expressions comparing standard fracture healing models with nonunion models in rats 12w, male, Sprague–Dawley rats were used in this study. Animals were randomized to receive either a surgical treatment that has been shown to produce a nonunion or to a standard stabilized closed f...
ORGANISM(S): Rattus norvegicus 
2015-09-03 | E-GEOD-55088 | biostudies-arrayexpress
MetabolomicsInhibiting glutaminase exerts opposite effects on ovariectomy-induced and age-related reductions in murine bone mass
Recent studies have provided links between glutamine metabolism and bone remodeling, but little is known about its role in primary osteoporosis progression. We aimed to determine the effects of inhibiting glutaminase (GLS) on two types of primary osteoporosis and elucidate the related metabolism. To...
2024-06-17 | MTBLS9415 | MetaboLights
TranscriptomicsTranscription profiling time series of Rattus norvegicus femoral fracture healing in individuals aged 6, 26 and 52 weeks
A study of rat femoral fracture healing in young (6 weeks old at fracture), adult (26 weeks old at fracture), and old (52 weeks old at fracture) rats. Samples were collected at time of surgery (intact controls) and at 3 days, 1 week, 2 weeks, 4 weeks, and 6 weeks after fracture. Samples were the m...
ORGANISM(S): Rattus norvegicus 
2007-11-03 | E-GEOD-1371 | biostudies-arrayexpress
TranscriptomicsGene expression in alpha SMA Cre-labeled cells in periosteum during early fracture callus formation
Fracture healing is a process that involves many cell populations. In this study we characterized gene expression in a subset of cells involved in fracture healing. αSMACreERT2 mice crossed with Ai9 reporter mice that express tdTomato fluorescent protein after Cre-mediated activation were used as an...
ORGANISM(S): Mus musculus 
2013-11-27 | E-GEOD-45156 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of femoral fracture healing in Rattus norvegicus subjects comparing intramedullary nailing, screw and plate fixation, and sham surgery
This is a study of femoral fracture healing in female rats 16 weeks old at fracture to compare intramedullary nailing, screw and plate fixation, and sham surgery. The sham surgery group received a surgical exposure of the femur, but no fracture, no plate, and no nail. Samples were collected at 1 d...
ORGANISM(S): Rattus norvegicus 
2007-11-03 | E-GEOD-1685 | biostudies-arrayexpress
ProteomicsProteomic Analyses of Plasma from Patients with Fracture Related Infection Reveals Systemic Activation of the Complement and Coagulation Cascades
Patients/Participants: Twenty-seven patients meeting confirmatory FRI criteria were matched to 27 controls based on fracture region, age, and time after surgery Intervention: Tandem Mass Tag (TMT) LC-MS analysis of patient plasma samples Main Outcome Measurements: Abundances for over 1000 proteins w...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-10-15 | MSV000093116 | MassIVE
TranscriptomicsDifferentially regulated circulating microRNAs in post-menopausal women suffering from osteoporotic femoral-neck fractures
Osteoporosis is the consequence of altered bone metabolism resulting in the systemic reduction of bone strength and increased risk of fragility fractures. MicroRNAs (miRNAs) regulate gene expression on a post-transcriptional level are known to take part in the control of bone formation and bone reso...
ORGANISM(S): Homo sapiens 
2015-06-26 | E-GEOD-60230 | biostudies-arrayexpress
MetabolomicsPla2g7 regulates bone homeostasis via Alox12/12-HETE/Gpr31 signaling axis

Bone homeostasis mainly depends on the equilibrium of osteoclasts and osteoblasts, overactivated osteoclasts play a pivotal role in the progression of osteoporosis. Here, we revealed that Pla2g7 (phospholipase A2 group VII) was positively correlated with bone resorption in clinic. By single-cell ...

2025-10-30 | MTBLS13141 | MetaboLights
TranscriptomicsFracture healing in osteoporotic mice
Genome-wide comparative gene expression analysis of callus tissue of osteoporotic mice (Col1a1-Krm2 and Lrp5-/-) and wild-type were performed to identify candidate genes that might be responsible for the impaired fracture healing observed in Col1a1-Krm2 and Lrp5-/- mice. To investigate bone healing ...
ORGANISM(S): Mus musculus 
2013-10-25 | E-GEOD-51686 | biostudies-arrayexpress
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