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ProteomicsGenome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in NSCLC
Human non-small-cell lung cancers (NSCLCs) harboring activating mutations in epidermal growth factor receptor (EGFR) frequently respond to EGFR tyrosine kinase inhibitors (TKIs), such as erlotinib and gefitinib. However, the responses are not durable, and the magnitude of tumor regression is variabl...
ORGANISM(S): Homo sapiens (Human) 
2019-11-14 | PXD014198 | Pride
Cancer Human Egfr 
ProteomicsIdentification of critical therapeutic nodes to overcome Asparagine deprivation resistance in melanoma
Asparagine deprivation by L-Asparaginase is a successful therapeutic strategy in Acute Lymphoblastic Leukemia, with resistance occurring due to upregulation of ASNS. L-Asparaginase efficacy in solid tumors is hampered by dose-related toxicities. Large scale loss of function genetic screens identifie...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD015152 | Pride
Leukemia Asparagine Human 
ProteomicsIn vitro DDR1 signalling - Inhibition of DDR1-BCR signalling by nilotinib as a new therapeutic strategy for metastatic colorectal cancer
The clinical management of metastatic colorectal cancer (mCRC) faces major challenges. For instance, patients harbouring oncogenic mutations in RAS signalling do not respond to anti-EGFR targeted treatment. Therefore, RAS-independent therapies are needed. Interestingly nilotinib, a clinically approv...
ORGANISM(S): Homo sapiens (Human) 
2018-01-31 | PXD008582 | Pride
Signalling Metastatic colorectal cancer Ddr1 tyrosine kinase 
ProteomicsIn vivo DDR1 signalling - Inhibition of DDR1-BCR signalling by nilotinib as a new therapeutic strategy for metastatic colorectal cancer
The clinical management of metastatic colorectal cancer (mCRC) faces major challenges. For instance, patients harbouring oncogenic mutations in RAS signalling do not respond to anti-EGFR targeted treatment. Therefore, RAS-independent therapies are needed. Interestingly nilotinib, a clinically approv...
ORGANISM(S): Homo sapiens (Human) 
2018-01-31 | PXD008546 | Pride
Signalling Metastatic colorectal cancer Ddr1 tyrosine kinase 
ProteomicsTMEM41B is a novel regulator of autophagy and lipid mobilization
Autophagy maintains cellular homeostasis by targeting damaged organelles, pathogens or misfolded protein aggregates for lysosomal degradation. The autophagic process is initiated by the formation of autophagosomes, which can selectively enclose cargo via autophagy cargo receptors. A machinery of wel...
ORGANISM(S): Homo sapiens (Human) 
2018-08-20 | PXD010207 | Pride
Autophagy/ contact sites/ crispr/ lipid droplets/ tmem41b 
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