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MetabolomicsIntegrated GWAS and metabolomic analyses identified metabolic pathways and candidate genes involved in free asparagine accumulation in durum wheat grain

Free asparagine content is a key factor in acrylamide formation in wheat derivatives after high temperature processing. Therefore, the control of free asparagine levels is of interest in crop and food sciences. Our study aims to explore the natural variation in durum wheat to identify candidate g...

2025-05-23 | MTBLS10381 | MetaboLights
MetabolomicsInvestigating diet to control asparagine uptake as an adjunct to asparaginase treatment

Refinements of multidrug regimens, and particularly the addition of L-asparaginase, resulted in an immediate gain in survival for pediatric acute lymphoblastic leukemia patients. Yet L-asparaginase has substantial side effects which may require dose reductions or delays in subsequent doses. There...

2026-01-25 | MTBLS13764 | MetaboLights
ProteomicsAsparagine hydroxylation of the UBA domain in Cezanne (OTUD7B)
by DUBs need to be tightly controlled. Here, we identify asparagine hydroxylation as a novel posttranslational modification involved in the regulation of Cezanne (OTUD7B), a DUB that controls key cellular functions and signaling pathways. We demonstrate that Cezanne is a substrate for FIH1- and oxyg...
ORGANISM(S): Homo sapiens (Human) 
2020-01-24 | PXD015216 | Pride
Otu7b Deubiquitinases Hydroxylation Cezanne 
ProteomicsSelective Modification of Asparagine and Glutamine via Isohypsic Reaction
The selective modification of amino acids within proteins represents the epitome of a chemoselective reaction. Current protein modification techniques are constrained to nucleophilic and redox-active residues, restricting their ability to target amino acids outside this scope. Herein, we introduce t...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2026-05-25 | PXD055899 | Pride
Asparagine Ptm Chemical proteomics Glutamine 
GenomicsAsparagine availability controlsgerminal centre B cell homeostasis
Asparagine availability controlsgerminal centre B cell homeostasis
PRJNA951723 | ENA
GenomicsAsparagine starvation on histone methylation and gene expression
Asparagine starvation on histone methylation and gene expression
PRJNA849231 | ENA
GenomicsGene expression profiling of leukemia cells following asparagine depletion
Gene expression profiling of leukemia cells following asparagine depletion
PRJNA558797 | ENA
GenomicsAsparagine availability controls B cell homeostasis
Asparagine availability controls B cell homeostasis
PRJNA1161789 | ENA
TranscriptomicsTranscriptional responses of yeast to preferred and non-preferred nitrogen sources in C-lim chemostat cultures
Aerobic, glucose-limited chemostat cultures of Saccharomyces cerevisiae grown with six different nitrogen sources were subjected to transcriptome analysis. The use of chemostats enabled an analysis of nitrogen-source-dependent transcriptional regulation at a fixed specific growth rate. A selection o...
ORGANISM(S): Saccharomyces cerevisiae 
2007-02-28 | E-GEOD-6405 | biostudies-arrayexpress
GenomicsMolecular effects of ISRIB during asparagine deprivation
Molecular effects of ISRIB during asparagine deprivation
PRJNA521363 | ENA
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