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ProteomicsFIH regulates cellular metabolism through hydroxylation of the deubiquitinase OTUB1.
The asparagine hydroxylase, factor inhibiting HIF (FIH) confers oxygen-dependence upon the hypoxia-inducible factor (HIF), a master regulator of the cellular adaptive response to hypoxia. Studies investigating whether asparagine hydroxylation is a general regulatory oxygen-dependent modification hav...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080695 | MassIVE
GenomicsHydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster
This SuperSeries is composed of the following subset Series: GSE32362: Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster (Illumina HumanMethylation450 BeadChip) GSE33129: Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mamm...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-33130 | biostudies-arrayexpress
ProteomicsProlyl hydroxylation regulates protein degradation, synthesis and splicing in human induced pluripotent stem cell-derived cardiomyocytes
Protein hydroxylases are oxygen and alpha-ketoglutarate-dependent enzymes that catalyze hydroxylation of amino acids such as proline, thus linking oxygen and metabolism to enzymatic activity. Prolyl hydroxylation is a dynamic post-translational modification that regulates protein stability and prote...
ORGANISM(S): Homo sapiens (Human) 
2016-05-06 | PXD003621 | Pride
Lc-ms/ms Amino acid labeling Prolyl hydroxylation Ipsc-derived cardiomyocytes 
ProteomicsDetermining the hydroxylation status of NAA10-Trp38
NAA10 is the major human N-terminal acetyltransferase (NAT). The KAT activity of NAA10 towards hypoxia-inducible factor 1α (HIF-1α) was recently reported to depend on the hydroxylation at Trp38 of NAA10 by factor inhibiting HIF-1α (FIH). As a consequence, Trp38 hydroxylation status was proposed to a...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD023655 | Pride
Hydroxylation Asp-oh Asn-oh Naa10 Trp-oh Nat 
ProteomicsAsparagine hydroxylation of the UBA domain in Cezanne (OTUD7B)
by DUBs need to be tightly controlled. Here, we identify asparagine hydroxylation as a novel posttranslational modification involved in the regulation of Cezanne (OTUD7B), a DUB that controls key cellular functions and signaling pathways. We demonstrate that Cezanne is a substrate for FIH1- and oxyg...
ORGANISM(S): Homo sapiens (Human) 
2020-01-24 | PXD015216 | Pride
Otu7b Deubiquitinases Hydroxylation Cezanne 
ProteomicsProline hydroxylation of ChREBP
This project investigated proline hydroxylation of ChREBP. Proline hydroxylation was investigated in flag-IP enriched protein extracts from ChREBP-flag overexpressing HEK293 cells (A) and in ChREBP-IP enriched mouse liver protein (male, C57BL6/J) (B).
ORGANISM(S): Mus musculus (Mouse) 
2020-10-19 | PXD019137 | Pride
Hek293 Mouse liver Proline hydroxylation 
ProteomicsAsparagine hydroxylation is likely to be a reversible post-translational modification
Amino acid hydroxylation is a common post-translational modification, which generally regulates protein interactions or adds a functional group that can be further modified. Such hydroxylation is currently considered irreversible, necessitating the degradation and re-synthesis of the entire protein ...
ORGANISM(S): Hordeum vulgare (Barley) 
2020-03-23 | PXD013116 | Pride
Lc-ms/ms Hydroxylation Hypoxia Ptm 
ProteomicsDown-regulation of collagen hydroxylation in colorectal liver metastasis
Collagen, a major component of the extracellular matrix, is significantly upregulated in colorectal liver metastasis (CRLM) compared to liver tissue. Expression levels of specific collagen types in CRLM resemble those in colorectal cancer (CRC) and colon tissue. We investigated whether the collagen ...
ORGANISM(S): Homo sapiens (Human) 
2020-09-16 | PXD015015 | Pride
Crlm Liver Human Ptm Crc Collagen Colon Orbitrap fusion 
ProteomicsWidespread hydroxylation of unstructured lysine-rich protein domains by JMJD6
The Jumonji domaining-containing protein JMJD6 is a 2-oxoglutarate dependent dioxygenase that has been implicated in a broad range of biological functions. Cellular studies have implicated the enzyme in chromatin biology, transcription, DNA repair, mRNA splicing and co-transcriptional processing. Al...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2022-08-02 | PXD031221 | Pride
Human Lc-msms Hydroxylation Jmjd6 Lysine derivatisation 
ProteomicsPHD3-mediated HIV-2 Vpx peptide hydroxylation
This dataset contains comparative mass spectrometry analysis investigating proline hydroxylation of synthetic HIV-2 Vpx peptides under two conditions: with and without PHD3 enzyme treatment. The analysis was performed using a high-resolution mass spectrometer coupled to a nano-LC system. The dataset...
ORGANISM(S): Human Immunodeficiency Virus 2 
2025-04-03 | PXD059242 | JPOST Repository
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