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MetabolomicsAdipocyte-derived β-hydroxybutyrate confers metabolic resilience in multiple myeloma by stabilizing IRF4 via NAT10-mediated acetylation

Multiple myeloma (MM) remains an incurable hematologic malignancy despite advances in treatment. While obesity is a well-established risk factor, the underlying metabolic mechanisms by which adipocytes contribute to disease progression remain elusive. Here, we uncover a critical m...

2026-05-07 | MTBLS14445 | MetaboLights
TranscriptomicsThe effect of temperature on Natural Antisense Transcript (NAT) expression in Aspergillus flavus
Naturally occurring Antisense Transcripts (NATs) compose an emerging group of regulatory RNAs. These regulatory elements appear in all organisms examined, but little is known about global expression of NATs in fungi. Analysis of currently available EST sequences suggests that 352 cis NATs are pres...
ORGANISM(S): Aspergillus flavus 
2010-06-21 | E-GEOD-12594 | biostudies-arrayexpress
MetabolomicsThe effect of an NAT10 inhibitor (remodelin) on inflammation-related genes in the treatment of thalamic hemorrhage based on metabolic data

Thalamic hemorrhage is a disease caused by hemorrhage of the thalamic brain parenchyma and is accompanied by an inflammatory response during development. NAT10 has been associated with a wide range of diseases. The aim of this study was to explore the molecular mechanisms associated with the use ...

2025-11-13 | MTBLS11941 | MetaboLights
TranscriptomicsThe bile acid CoA ligase, FATP5, is necessary for NAT synthesis in the liver
This study aimed to investigate the overlap between hepatic NAT and the bile acid synthesis to identify additional enzymes involved in NAT synthesis in the liver. We sequenced livers high-fat fed mice the were either wild-type or with a single-amino acid substitution in fatty acid amide hydrolase (F...
ORGANISM(S): Mus musculus 
2026-03-02 | E-MTAB-15752 | biostudies-arrayexpress
ProteomicsProteomics of hepatoblastoma and NAT samples
Proteomics of hepatoblastoma, normal liver tissues and NAT samples before or after chemotherapy.
ORGANISM(S): Homo Sapiens 
2024-11-13 | PXD057828 |
TranscriptomicsGenome-wide analysis for rice small RNAs by MPSS
Small RNAs (21-24 nt) are involved in gene regulation through translation inhibition, mRNA cleavage, or directing chromatin modifications. In rice, currently ~240 miRNAs have been annotated. We sequenced more than four million small RNAs from rice and identified another 24 miRNA genes. Among these, ...
ORGANISM(S): Oryza sativa 
2008-02-14 | E-GEOD-10523 | biostudies-arrayexpress
TranscriptomicsExpression of Arabidopsis cis-NAT pairs in inflorescences, leaves and roots
We systematically identified long noncoding natural antisense transcripts (lncNATs), defined as lncRNAs transcribed from the opposite DNA strand of coding or noncoding genes. We identified in total 37,238 sense-antisense transcript pairs and found 70% mRNAs are associated with antisense transcripts ...
ORGANISM(S): Arabidopsis thaliana 
2013-12-23 | E-GEOD-49381 | biostudies-arrayexpress
GenomicsBacterial NAT genes
Comparative investigation of 16 xenobiotic metabolizing N-acetyltransferase (NAT) homologs from bacteria
PRJEB39775 | ENA
TranscriptomicsDynamic changes of Arabidopsis cis-NAT pairs during de-etiolation
We systematically identified long noncoding natural antisense transcripts (lncNATs), defined as lncRNAs transcribed from the opposite DNA strand of coding or noncoding genes. We identified in total 37,238 sense-antisense transcript pairs and found 70% mRNAs are associated with antisense transcripts ...
ORGANISM(S): Arabidopsis thaliana 
2013-12-23 | E-GEOD-49382 | biostudies-arrayexpress
ProteomicsInvestigating peptide-Coenzyme A-conjugates as chemical probes for proteomic profiling of N-terminal and lysine acetyltransferases
Acetyl groups are transferred from Acetyl-Coenzyme A (Ac-CoA) to protein N-termini and lysine side chains by N-terminal acetyltransferases (NATs) and lysine acetyltransferases (KATs), respectively. Building on lysine-CoA conjugates as KAT probes, we have synthesized peptide probes with CoA conjugate...
ORGANISM(S): Homo Sapiens (human) 
2022-05-02 | PXD032957 | JPOST Repository
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