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TranscriptomicsEffects of knockdown of Jmjd6 on human umbilical vein endothelial cells - gene and exon expression
Human umbilical vein endothelial cells (HUVECs) were incubated for 48 h after transfection of scrambled siRNA or siRNA targeting Jmjd6 . Changes in transcript and exon levels were analyzed. 6 samples; 2 conditions: Scrambled siRNA vs. siJmjd6 ; 3 replicates per condition
ORGANISM(S): Homo sapiens 
2012-05-03 | E-GEOD-37741 | biostudies-arrayexpress
ProteomicsJMJD6 interactome screen from "Widespread hydroxylation of unstructured lysine-rich protein domains by JMJD6"
The Jumonji domaining-containing protein JMJD6 is a 2-oxoglutarate dependent dioxygenase that has been implicated in a broad range of biological functions. Cellular studies have implicated the enzyme in chromatin biology, transcription, DNA repair, mRNA splicing and co-transcriptional processing. Al...
ORGANISM(S): Homo sapiens (Human) 
2022-08-02 | PXD031155 | Pride
Lc-msms Dia Human Hela Interactome Orbitrap fusion lumos Jmjd6 
ProteomicsWidespread hydroxylation of unstructured lysine-rich protein domains by JMJD6
The Jumonji domaining-containing protein JMJD6 is a 2-oxoglutarate dependent dioxygenase that has been implicated in a broad range of biological functions. Cellular studies have implicated the enzyme in chromatin biology, transcription, DNA repair, mRNA splicing and co-transcriptional processing. Al...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2022-08-02 | PXD031221 | Pride
Human Lc-msms Hydroxylation Jmjd6 Lysine derivatisation 
TranscriptomicsKnock-down and Over-expression of JMJD6 in MCF-7 and/or MDA-MB231
By survival analysis of breast cancer patients, JMJD6 was found to be significantly associated with poor prognosis. Over-expression and knock-down of JMJD6 in breast cancer cell lines suggested a role in proliferation. In order to study the transcriptional events that occur following JMJD6 expressio...
ORGANISM(S): Homo sapiens 
2012-05-09 | E-GEOD-31782 | biostudies-arrayexpress
TranscriptomicsBrd4 and JMJD6-associated Anti-pause Enhancers in Regulation of Transcriptional Pause Release
Distal enhancers characterized by H3K4me1 mark play critical roles in developmental and transcriptional programs. However, potential roles of specific distal regulatory elements in regulating RNA Polymerase II (Pol II) promoter-proximal pause release remain poorly investigated. Here we report that a...
ORGANISM(S): Homo sapiens 
2014-01-14 | E-GEOD-51633 | biostudies-arrayexpress
GenomicsiBET JMJD6
Aligned BAM files for PCa cell lines (iBET treated and JMJD6 siRNA)
PRJEB49820 | ENA
TranscriptomicsGlobal gene expression profiling of Jmjd6- and Jmjd4-depleted mouse NIH3T3 fibroblasts
Emerging evidence suggests Jumonji domain-containing proteins are epigenetic regulators in diverse biological processes including cellular differentiation and proliferation. RNA interference-based analyses combined with gene expression profiling can effectively characterize the cellular functions of...
ORGANISM(S): Mus musculus 
2016-01-12 | E-GEOD-76758 | biostudies-arrayexpress
TranscriptomicsTranscriptomes of triple-negative breast cancer (TNBC) cells (SUM159) and non-TNBC cells (HCC1569) that overexpressed JMJD6 were compared
The expression levels of JMJD6 and its correlation with H2A.XY39ph differed in TNBC and non-TNBC cells. In addition, we have previously shown that H2A.XY39ph levels are positively correlated with tumor size, histological grade and advanced TNM stage in breast cancer. To analyze the role of JMJD6 in ...
ORGANISM(S): Homo sapiens 
2023-10-01 | E-MTAB-6517 | biostudies-arrayexpress
GenomicsGeneration of JMJD6 KO in several human cell lines
Generation of JMJD6 KO in several human cell lines
PRJNA1499749 | ENA
GenomicsJMJD6-DGAT1 Signaling Regulates Lipid Metabolism and Tumorigenesis in ccRCC
JMJD6-DGAT1 Signaling Regulates Lipid Metabolism and Tumorigenesis in ccRCC
PRJNA758160 | ENA
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