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ProteomicsSite-specific 5-hydroxy-tryptophan incorporation into apolipoprotein A-I impairs cholesterol efflux activity and high density lipoprotein biogenesis
We used genetic code expansion technology with an engineered Saccharomyces cerevisiae tryptophanyl tRNA- synthetase:suppressor tRNA pair in Escherichia coli, to directly insert the non- canonical amino acid 5-OH tryptophan (5-OHTrp) at position 72 in human apoA-I. Characterization of recombinant hum...
ORGANISM(S): Homo sapiens (Human) 
2020-03-02 | PXD017226 | Pride
Plasma Apolipoprotein a-i 5-oh-trp Human 
ProteomicsDetermining the hydroxylation status of NAA10-Trp38
NAA10 is the major human N-terminal acetyltransferase (NAT). The KAT activity of NAA10 towards hypoxia-inducible factor 1α (HIF-1α) was recently reported to depend on the hydroxylation at Trp38 of NAA10 by factor inhibiting HIF-1α (FIH). As a consequence, Trp38 hydroxylation status was proposed to a...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD023655 | Pride
Hydroxylation Asp-oh Asn-oh Naa10 Trp-oh Nat 
UnknownFractalkine, sICAM-1 and Kynurenine Pathway in Restrictive Anorexia Nervosa-Exploratory Study.
Not available
S-EPMC7910978 | biostudies-literature
UnknownTryptophan and Non-Tryptophan Fluorescence of the Eye Lens Proteins Provides Diagnostics of Cataract at the Molecular Level.
Not available
S-EPMC5223181 | biostudies-literature
Unknown4-isopropylcyclohexanol has potential analgesic effects through the inhibition of anoctamin 1, TRPV1 and TRPA1 channel activities.
Not available
S-EPMC5320485 | biostudies-literature
UnknownTryptophan Ameliorates Metabolic Syndrome by Inhibiting Intestinal Farnesoid X Receptor Signaling: The Role of Gut Microbiota-Bile Acid Crosstalk.
Not available
S-EPMC11638488 | biostudies-literature
UnknownIncreased expression of kynurenine aminotransferases mRNA in lymphocytes of patients with inflammatory bowel disease.
Not available
S-EPMC6801885 | biostudies-literature
UnknownEnzymatic Mechanism of Leishmania major Peroxidase and the Critical Role of Specific Ionic Interactions.
Not available
S-EPMC4533909 | biostudies-literature
UnknownDe novo designed aliphatic and aromatic peptides assemble into amyloid-like cytotoxic supramolecular nanofibrils.
Not available
S-EPMC10831423 | biostudies-literature
UnknownDifferentiation of chiral phosphorus enantiomers by P and H NMR spectroscopy using amino acid derivatives as chemical solvating agents.
Not available
S-EPMC2084221 | biostudies-literature
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