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GenomicsGene expression profiling of colorectal cancer liver metastases (CRLM).
Gene expression profiling of colorectal cancer liver metastases (CRLM).
PRJNA668063 | ENA
ProteomicsDown-regulation of collagen hydroxylation in colorectal liver metastasis
Collagen, a major component of the extracellular matrix, is significantly upregulated in colorectal liver metastasis (CRLM) compared to liver tissue. Expression levels of specific collagen types in CRLM resemble those in colorectal cancer (CRC) and colon tissue. We investigated whether the collagen ...
ORGANISM(S): Homo sapiens (Human) 
2020-09-16 | PXD015015 | Pride
Crlm Liver Human Ptm Crc Collagen Colon Orbitrap fusion 
UnknownHepatocellular carcinoma (HCC) tumor microenvironment is more suppressive than colorectal cancer liver metastasis (CRLM) tumor microenvironment.
Not available
S-EPMC11014815 | biostudies-literature
TranscriptomicsIdentification of molecular pathways involved in oxaliplatin-associated sinusoidal dilatation
Oxaliplatin-based chemotherapy for colorectal liver metastases (CRLM) can result in vascular liver lesions such as sinusoidal dilatations. Physiopathology remains unclear and variability between patients suggests that there is individual susceptibility. A better understanding of the molecular mechan...
ORGANISM(S): Homo sapiens 
2012-03-01 | E-GEOD-32384 | biostudies-arrayexpress
UnknownPrognostic analysis of patients with CRLM based on CRS score: a single-center retrospective study.
Not available
S-EPMC12004860 | biostudies-literature
UnknownMapping fibrosis in colorectal liver metastases (CRLM) with gadobenate dimeglumine-enhanced MRI: prognostic implications and imaging biomarkers.
Not available
S-EPMC12923479 | biostudies-literature
ProteomicsProteomic Profiling of Colorectal Liver Metastases Reveals Histopathological Response-Specific Molecular Signatures of Chemotherapy Efficacy
Background: Chemoresistance in treatment of colorectal liver metastases (CRLM) poses a serious challenge in preventing disease relapse, with up to 80% of patients developing drug resistance over the course of treatment. Proteomic signatures of responsive vs. non-responsive metastases can provide in...
ORGANISM(S): Homo sapiens (Human) 
2026-04-13 | PXD065812 | Pride
Human  crlm  crc 
ProteomicsIdentification of 4-Hydroxyproline at the Xaa Position in Collagen by Mass Spectrometry
Collagen has a triple helix form, structured by a [-Gly-Xaa-Yaa-] repetition, where Xaa and Yaa are amino acids. This repeating unit can be post-translationally modified by enzymes, where proline is often hydroxylated into hydroxyproline (Hyp). Two Hyp isomers occur in collagen: 4-hydroxyproline (4H...
ORGANISM(S): Homo sapiens (Human) 
2019-03-20 | PXD011784 | Pride
Ab initio Colorectal liver metastasis Mass spectrometry Collagen Ptm Liver Etd Hydroxyproline Posttranslational modification Orbitrap fusion 
UnknownIndividualized Selection Criteria Based on Tumor Burden in Future Remnant Liver for Staged Hepatectomy of Advanced CRLM: Conventional TSH or ALPPS.
Not available
S-EPMC9324888 | biostudies-literature
ProteomicsTissue Slide Proteomics of Primary Liver Cancer, Colorectal Cancer Liver Metastases and Colorectal Cancer
FFPE tissue specimens from 54 patients who underwent surgery at the Affiliated Hospital of Jiangnan University were selected for the study.we employed FFPE slides from CRC, CRLM, and HCC patients to undertake rapid proteomics analysis. Subsequently, we conducted differential protein intensity and fu...
ORGANISM(S): Homo Sapiens 
2023-06-02 | PXD042636 |
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