Sort   by:  
 Page size 
ProteomicsBiopsy proteome-based classification of T-cell-mediated kidney allograft rejection
T cell-mediated rejection (TCMR) remains a challenge in kidney transplantation. Based on a histopathological biopsy examination, patients can be classified into groups defining their kidney’s status, i.e. no rejection (NR), borderline rejection (BR) and acute rejection (AR). Yet, this classification...
ORGANISM(S): Homo sapiens (Human) 
2025-10-27 | PXD064523 | Pride
Borderline rejection Kidney transplant rejection Immunohistochemical staining T-cell mediated rejection Mass spectrometry proteomics 
TranscriptomicsMolecular diagnosis of T cell and/or antibody-mediated rejection in human kidney transplant biopsies
Histologic diagnosis of T cell-mediated rejection in kidney transplant biopsies has limited reproducibility because it is based on non-specific lesions using arbitrary rules that are subject to differing interpretations. We used microarray results from 403 indication biopsies previously given histol...
ORGANISM(S): Homo sapiens 
2013-02-13 | E-GEOD-36059 | biostudies-arrayexpress
TranscriptomicsExpression of the IL-17/Th17 axis in the development of acute renal allograft rejection
Genesets for the IL-17 pathway and Th17 T-helper cell subtype showed increasing enrichment in 33 pre-transplant donor biopsies and 33 matching post-transplant biopsies from patients with increasing Banff grades of acute rejection (no signficant abnormalities, n=17; borderline, n=4; ARIA, n=7; ARIB, ...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-34437 | biostudies-arrayexpress
TranscriptomicsSingle Nucleus RNA Sequencing of Human Kidney Allografts with Cellular Rejection
Kidney transplant recipients are currently treated with nonspecific immunosuppressants that cause severe systemic side effects. Current immunosuppressants were developed based on their effect on T-cell activation rather than the underlying mechanisms driving alloimmune responses. Thus, understanding...
ORGANISM(S): Homo sapiens 
2023-03-28 | GSE228300 | GEO
TranscriptomicsPeripheral blood biomarker signatures for acute kidney transplant rejection
In the present work, we have used whole genome expression profiling of peripheral blood samples from 51 patients with biopsy-proven acute kidney transplant rejection and 24 patients with excellent function and biopsy-proven normal transplant histology. The results demonstrate that there are 1738 pro...
ORGANISM(S): Homo sapiens 
2014-03-01 | E-GEOD-15296 | biostudies-arrayexpress
GenomicsSingle Nucleus RNA Sequencing of Human Kidney Allografts with Cellular Rejection
Single Nucleus RNA Sequencing of Human Kidney Allografts with Cellular Rejection
PRJNA949220 | ENA
Methylation profilingTotal plasma cfDNA methylation in kidney transplant recipients provides insight into acute allograft rejection pathophysiology
Acute rejection threatens kidney allograft longevity. Cell-free DNA (cfDNA) is a real-time marker of organ injury and immune response. DNA methylation is an epigenetic marker that regulates gene expression. We aim to elucidate differential methylation of total plasma cfDNA between pediatric kidney t...
ORGANISM(S): Homo sapiens 
2025-04-25 | GSE275017 | GEO
UnknownEvidence for the alloimmune basis and prognostic significance of Borderline T cell-mediated rejection.
Not available
S-EPMC7496654 | biostudies-literature
TranscriptomicsRenal allograft dysfunction
The study comprises various components: We aim to screen out different gene expression profile in acute rejection on the kidney. We aim to screen out different gene expression profile in acute tubular necrosis on the kidney. We aim to screen out different gene expression profile in borderline change...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-19130 | biostudies-arrayexpress
GenomicsTotal plasma cfDNA methylation in kidney transplant recipients provides insight into acute allograft rejection pathophysiology
Total plasma cfDNA methylation in kidney transplant recipients provides insight into acute allograft rejection pathophysiology
PRJNA1148968 | ENA
Sort   by:  
 Page size