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TranscriptomicsMultiple Origins of Virus Persistence during Natural Control of HIV Infection
Targeted HIV cure strategies require definition of the mechanisms that maintain the virus. Here, we tracked HIV replication and the persistence of infected CD4 T cells in individuals with natural virologic control by sequencing viruses, T cell receptor genes, HIV integration sites and cellular trans...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-83482 | biostudies-arrayexpress
TranscriptomicsType I IFN responses in rhesus macaques prevent SIV transmission and slow disease progression
In acute HIV infection immune activation may provide target cells and drive virus replication, which innate immunity may limit. Thus, the net effects of inflammatory mediators, including type I interferon (IFN-I), are unclear. Here, we block IFN-I signaling during pathogenic acute SIV infection wit...
ORGANISM(S): Macaca mulatta 
2014-07-23 | E-GEOD-53690 | biostudies-arrayexpress
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