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TranscriptomicsGene expression patterns in responding versus non-responding AB1-HA tumors from mice during immunotherapy
Balb/c mice were inoculated subcutaneously with AB1-HA cells on both flanks on day 0. The mice were then treated with anti-CTLA-4 on day 5 or 6. 7 days later, one tumor was removed for gene expression studies, and the other was left in situ to monitor tumor growth and determine if the eventual outco...
ORGANISM(S): Mus musculus 
2015-07-22 | E-GEOD-63557 | biostudies-arrayexpress
TranscriptomicsGene expression patterns in house dust mite stimulated CD4 T cells and IgG:IgE ratios
PBMC from house dust mite (HDM) sensitized atopics were cultured in the presence or absence of HDM extract for 24 hours. At the termination of the cultures, CD4 T cells were isolated using immunomagnetic separation. Gene expression was profiled on microarrays. The study design consisted of 45 subjec...
ORGANISM(S): Homo sapiens 
2015-11-03 | E-GEOD-70760 | biostudies-arrayexpress
TranscriptomicsGlobal expression profiling of CD4 T-cell responses to house dust mite allergens in human atopics and nonatopics.
The aim of this study was to employ a systems-level analysis to elucidate gene expression networks operating in the CD4 T-cell responses which underpin human atopic disease. Keywords: Disease state analysis; T-cell response The study design consisted of 45 subjects, including 30 HDM-sensitized atop...
ORGANISM(S): Homo sapiens 
2009-05-05 | E-GEOD-14908 | biostudies-arrayexpress
TranscriptomicsVirus-induced inflammatory gene networks underlying asthma exacerbations in vivo
Global patterns of gene expression was profiled in nasal lavage samples obtained from asthmatic children during an acute Picornavirus-induced exacerbation and 7-14 days later. Gene coexpression network analysis and prior knowledge was employed to reconstruct the wiring diagram of the underlying gene...
ORGANISM(S): Homo sapiens 
2011-12-11 | E-GEOD-30326 | biostudies-arrayexpress
TranscriptomicsGenomic responses in blood during acute human anaphylaxis
Gene expression was profiled in peripheral blood samples collected over three time points from patients during acute anaphylaxis and from healthy controls. Patients presented to the Emergency Department (ED) at Royal Perth Hospital with acute, moderately severe anaphylaxis. Samples were collected at...
ORGANISM(S): Homo sapiens 
2014-07-02 | E-GEOD-47655 | biostudies-arrayexpress
ProteomicsMulticohort analysis unveils axon guidance pathways linking small for gestational age to spirometric restriction.
Children born small for gestational age (SGA) face elevated risks of metabolic, cardiovascular, respiratory, and neurodevelopmental disorders, as well as premature mortality, yet the underlying mechanisms remain only partly understood. We analyze blood proteomic data from multiple birth cohorts to i...
ORGANISM(S): Homo sapiens (Human) 
2026-04-02 | PAD000036 | Pride
Small for gestational age Cord blood Proteomics Somascan 
TranscriptomicsIn utero exposure to arsenic via drinking water impairs lung development and mucociliary clearance genes.
In utero exposure to arsenic via drinking water increases the risk of lower respiratory tract infections during infancy and mortality from bronchiectasis in adulthood. Pregnant mice were exposed to arsenic, and gene expression patterns were profiled in peripheral lung tissue obtained from the offspr...
ORGANISM(S): Mus musculus 
2013-06-04 | E-GEOD-37831 | biostudies-arrayexpress
TranscriptomicsGene expression patterns in allergen-driven CD4 T cell responses from human atopics with or without asthma.
PBMC from house dust mite (HDM) sensitized atopics with or without asthma (or nonallergic controls) were cultured in the presence or absence of HDM extract for 24 hours. At the termination of the cultures, immunomagnetic separation was performed to purify CD4 T cells. Gene expression was profiled on...
ORGANISM(S): Homo sapiens 
2016-02-25 | E-GEOD-73482 | biostudies-arrayexpress
TranscriptomicsPneumococcal conjugate vaccination at birth induces robust recall responses at 9 months of age.
The objective of this study was to compare recall responses to vaccine antigens at 3 months and 9 months of age in infants who were vaccinated at birth or at 1 month. PBMC were obtained at 9 months of age from infants who were vaccinated at birth (n=25) or 1 month (n=25). The PBMC were cultured in t...
ORGANISM(S): Homo sapiens 
2011-06-27 | E-GEOD-25263 | biostudies-arrayexpress
TranscriptomicsRole of IRF7 in airway epithelial cell responses to human rhinovirus infection.
Primary human bronchial epithelial cells were transfected with siRNA to knockdown IRF7 gene expression, allowed to recover, and then infected with human rhinovirus. At 24 hrs post rhinovirus infection, gene expression patterns were profiled on microarrays. The study design consisted of five donors, ...
ORGANISM(S): Homo sapiens 
2016-01-10 | E-GEOD-70190 | biostudies-arrayexpress
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