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TranscriptomicsTranscription profiling of liver from mice with constitutively active Hypoxia Inducible Factor (HIF-1a and HIF-2a) or inactivated von Hippel-Lindau tumor suppressor gene product (pVHL)
The effects of constitutively active Hypoxia Inducible Factor (HIF) and inactivated von Hippel-Lindau tumor suppressor gene product (pVHL) were examined in a mouse model. Conditionally expressed, constitutively active HIF-1a and HIF-2a were compared with inactivated pVHL.
ORGANISM(S): Mus musculus 
2006-09-21 | E-MEXP-856 | biostudies-arrayexpress
TranscriptomicsBeta-catenin Controls Metastasis in Braf-activated Pten-inactivated Melanomas
Malignant melanoma is characterized by frequent metastasis, however specific changes that regulate this process have not been clearly delineated. Although it is well known that Wnt signaling is frequently dysregulated in melanoma, the functional implications of this observation are unclear. By modul...
ORGANISM(S): Mus musculus 
2011-10-12 | E-GEOD-32907 | biostudies-arrayexpress
TranscriptomicsPro-invasion metastasis drivers in early stage melanoma are oncogenes
Clinical and genomic evidence support the view that the metastatic potential of a primary tumor may be dictated by transforming events acquired early in the tumorigenic process. It has been proposed that the presence of such pro-metastatic events in early-stage tumors reflects their additional capa...
ORGANISM(S): Mus musculus 
2011-07-11 | E-GEOD-29074 | biostudies-arrayexpress
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