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TranscriptomicsTranscriptional profiling of experimental CD8+ lymphocyte depletion in rhesus macaques infected with SIVmac239
CD8+ T-cells inhibit virus replication in SIV-infected rhesus macaques (RM). However, it is unclear to what extent the viral suppression mediated by CD8+ T-cells reflects direct killing of infected cells as opposed to indirect, non-cytolytic mechanisms. In this study, we used functional genomics to ...
ORGANISM(S): Macaca mulatta 
2013-02-08 | E-GEOD-37834 | biostudies-arrayexpress
TranscriptomicsCataloguing of Potential HIV Susceptibility Factors during the Menstrual Cycle of Pigtail Macaques
Our earlier studies in pig-tailed macaques demonstrated varying SHIV susceptibility during the menstrual cycle, likely caused by cyclic variations in immune responses in the female genital tract. There is concern that high-dose, long-lasting, injectable progestin-based contraception could mimic the...
ORGANISM(S): Macaca nemestrina 
2015-07-08 | E-GEOD-68079 | biostudies-arrayexpress
TranscriptomicsMurine DN T-reg cells impart prolonged cardiac allograft survival
Recent studies have demonstrated that both mouse and human alpha beta TCR(+)CD3(+)NK1.1(-)CD4(-)CD8- double-negative regulatory T (DN Treg) cells can suppress Ag-specific immune responses mediated by CD8+ and CD4+ T cells. To identify molecules involved in DN Treg cell function, we generated a panel...
ORGANISM(S): Mus musculus 
2005-07-29 | E-GEOD-3024 | biostudies-arrayexpress
TranscriptomicsType I IFN responses in rhesus macaques prevent SIV transmission and slow disease progression
In acute HIV infection immune activation may provide target cells and drive virus replication, which innate immunity may limit. Thus, the net effects of inflammatory mediators, including type I interferon (IFN-I), are unclear. Here, we block IFN-I signaling during pathogenic acute SIV infection wit...
ORGANISM(S): Macaca mulatta 
2014-07-23 | E-GEOD-53690 | biostudies-arrayexpress
TranscriptomicsColorectal tissue gene expression in SIV negative and SIV positive Rhesus macaques and sooty mangabeys
In SIV/HIV infection, the gastrointestinal tissue dominates as an important site due to the impact of massive mucosal CD4 depletion and immune activation-induced tissue pathology. Unlike AIDS-susceptible rhesus macaques, natural hosts do not progress to AIDS and resolve immune activation earlier. He...
ORGANISM(S): Macaca mulatta 
2011-09-05 | E-GEOD-29980 | biostudies-arrayexpress
UnknownHigh throughput analysis of B cell dynamics and neutralizing antibody development during immunization with a novel clade C HIV-1 envelope.
Not available
S-EPMC10627474 | biostudies-literature
TranscriptomicsTranscription profiling of mouse double-negative regulatory T Cells
Lee et al. (2005)Expression Profiling of Murine Double-Negative Regulatory T Cells Suggest Mechanisms for Prolonged Cardiac Allograft Survival. The Journal of Immunology, 2005, 174: 4535 4544. Type 2 experiment where functional DN T-reg cells (CN4 or TN12) were cy-3 labeled and co-hybridized with n...
ORGANISM(S): Mus musculus 
2005-07-21 | E-SMDB-3283 | biostudies-arrayexpress
UnknownIncreased IL-6 expression precedes reliable viral detection in the rhesus macaque brain during acute SIV infection.
Not available
S-EPMC8564899 | biostudies-literature
MetabolomicsFeatures of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study
Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficit...
2024-01-12 | MTBLS850 | MetaboLights
UnknownType I and Type III Interferons Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures.
Not available
S-EPMC7495371 | biostudies-literature
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