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TranscriptomicsMeasuring the effects of pervasive transcription on promoter activity in Salmonella Pathogenicity Island 1 by semiquantitative 5’RACE-Seq
Pervasive Transcription originates from spurious promoters present in both orientations within coding sequences. Spurious transcripts are typically untranslated and thus for the most part are terminated by transcription termination factor Rho. They can be studied by impairing Rho activity, which in ...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 
2022-07-04 | E-MTAB-11419 | biostudies-arrayexpress
Transcriptomics5'-RACE-Seq analysis of Salmonella hilD and leuO promoters' response to adjacent transcription
Gene silencing by nucleoid-associated protein H-NS is sensitive to neighbouring transcription. This effect does not require neighbouring transcription to elongate into the silenced region. Here we measured how activating transcription of a tetRA cassette positioned upstream of either hilD or leuO pr...
ORGANISM(S): Salmonella enterica subsp. enterica 
2024-10-19 | E-MTAB-13482 | biostudies-arrayexpress
GenomicsComparing the chromosome binding profiles of nucleoid structuring protein H-NS in the presence or absence of conditions eliciting the depletion of transcription termination protein NusG in Salmonella
Not available
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 
2022-07-04 | E-MTAB-11386 | biostudies-arrayexpress
GenomicsChIP-Seq analysis of H-NS binding profiles in a Salmonella strain with a tetRA cassette insertion in Pathogenicity-Island-1 grown in the presence or in the absence of the tetRA inducer AHTc
Nucleoid structuring protein H-NS silences the expression of Salmonella Pathogenicity Island 1 (SPI-1) by binding to the promoter region of SPI-1's master regulator. The experiment aims at testing whether transcription of sequences more than one Kb upstream of the regulator gene causes H-NS:DNA comp...
ORGANISM(S): Salmonella enterica subsp. enterica 
2024-10-06 | E-MTAB-13436 | biostudies-arrayexpress
TranscriptomicsEffects of Rho mutations Y80C and K130Q on the Salmonella transcriptome
Understanding the connection between transcription termination and H-NS-mediated gene silencing in bacteria
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2019-09-20 | E-MTAB-8206 | biostudies-arrayexpress
TranscriptomicsTranscriptional response to NusG depletion in Salmonella
Understanding the role of transcription termination in H-NS-mediated gene silencing
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2019-09-20 | E-MTAB-8159 | biostudies-arrayexpress
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