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ProteomicsKidney proteomics in the folic acid (FA) induced nephropathy mouse model
Treatments for kidney fibrosis represent an urgent yet unmet clinical need. Effective therapies are limited due to not well understood molecular pathogenesis. We aimed at generating a comprehensive and integrated multi-omics data set (RNA/ microRNA transcriptomics and proteomics) of fibrotic kidneys...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-09 | PXD011453 | Pride
Ckd Fibrosis Mouse Kidney 
ProteomicsKidney proteomics in the unilateral ureter obstruction (UUO) mouse model
Treatments for kidney fibrosis represent an urgent yet unmet clinical need. Effective therapies are limited due to not well understood molecular pathogenesis. We aimed at generating a comprehensive and integrated multi-omics data set (RNA/ microRNA transcriptomics and proteomics) of fibrotic kidneys...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-09 | PXD010861 | Pride
Ckd Fibrosis Mouse Kidney 
ProteomicsTotal protein profiles of human induced pluripotent stem cell-derived cardiomyocytes in response to four tyrosine kinase inhibitors
Drug-induced cardiotoxicity is a widespread clinical issue affecting numerous drug classes and remains difficult to treat. One such drug class is Tyrosine Kinase Inhibitors (TKIs), which cause varying degrees of contraction-related cardiotoxicity usually after weeks of exposure. Understanding molecu...
ORGANISM(S): Homo sapiens (Human) 
2019-05-16 | PXD012043 | Pride
Tyrosine kinase inhibitor Cardiotoxicity Aerobic glycolysis Human induced pluripotent stem cell-derived cardiomyocyte Mitochondrial respiration Drug adaptation Tandem mass tag mass spectrometry 
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