Sort   by:  
 Page size 
MetabolomicsThe gut microbiota-butyrate axis restores cardiomyocyte autophagy to alleviate Doxorubicin-induced cardiotoxicity

Abstract

Background Doxorubicin (DOX), an anthracycline chemotherapeutic agent, is widely used for treating various malignancies. However, its clinical application is limited by dose-dependent cardiotoxicity (DOX-induced cardiotoxicity, DIC). Recent studies have shown that the gut microbiot...

2025-09-16 | MTBLS12997 | MetaboLights
MetabolomicsMicrobiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against αPD1-induced cardiotoxicity in mice
Anti-programmed death 1 (αPD1) immune checkpoint blockade is used in combination for cancer treatment but associated with cardiovascular toxicity. Finding drugs that suppress cardiovascular toxicity but not compromise the efficacy of αPD1-mediated immunotherapy is of great importance. Leflunomide (L...
2025-03-12 | MTBLS12066 | MetaboLights
MetabolomicsProteasome Inhibitor Related Cardiotoxicity (part II)
Not available
ORGANISM(S): Mus musculus 
ST001858 | MetabolomicsWorkbench
MetabolomicsProteasome Inhibitor Related Cardiotoxicity (part I)
Not available
ORGANISM(S): Mus musculus 
ST001846 | MetabolomicsWorkbench
ProteomicsAntipsychotic cardiotoxicity and its mechanisms
Antipsychotic (AP) drugs are common agents for treating mental disorders such as schizophrenia, bipolar disorder, and major depressive disorder. Overall AP prescription increased 3.8-fold, while second-generation AP (SGA) prescriptions increased 18.1-fold during a 16-year follow-up. The increased us...
ORGANISM(S): Mus Musculus 
2021-12-22 | PXD030588 |
ProteomicsProteomic cellular signatures of kinase inhibitor-induced cardiotoxicity
Drug Toxicity Signature Generation Center (DToxS) at the Icahn School of Medicine at Mount Sinai is an integral part of the NIH Library of Integrated Network-Based Cellular Signatures (LINCS) program. A key aim of DToxS is to generate both proteomic and transcriptomic signatures that cab predict adv...
ORGANISM(S): Homo sapiens (Human) 
2021-10-18 | PXD014791 | Pride
Cardiotoxicity Drug Signature Proteomics Mass spectrometry Kinase inhibitor 
ProteomicsUbiquitome profiling uncovers disturbed mitochondrial remodeling as an outcome of doxorubicin-induced cardiotoxicity in old mice
The urgent need to understand the molecular modulation associated with chronic cardiotoxicity of doxorubicin (DOX) has prompted us to investigate the ubiquitome profile of aged cardiac muscle. Using old CD-1 male mice administered with a DOX dosage established to induce cardiotoxicity, we performed ...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-30 | PXD048078 | Pride
Mitochondrial dynamics Old Chronic cardiotoxicity Ubiquitination Anticancer therapy Cardio-oncology 
MetabolomicsMitochondrial Transplantation Ameliorates Doxorubicin-Induced Cardiac Dysfunction via Activating Glutamine Metabolism
Doxorubicin is a wildly used effective anticancer agent. However, doxorubicin use is also related to cardiotoxic side effect in some patients. Mitochondrial damage has been shown to be one of the pathogeneses of doxorubicin-induced myocardial injury. In this study, we test the hypothesis that mitoch...
2025-03-13 | MTBLS7989 | MetaboLights
TranscriptomicsMicroRNA array profiling on human pluripotent stem cell-derived cardiomyocytes exposed to doxorubicin
Cardiomyocytes derived from human pluripotent stem cells were exposed to the cardiotoxic drug Doxorubicin in order to assess the utility of this cell system as a model for drug-induced cardiotoxicity. Cells are exposed to different concentrations of doxorubicin for up to 48 hours followed by a 12 da...
ORGANISM(S): Homo sapiens 
2017-10-28 | E-MTAB-6052 | biostudies-arrayexpress
GenomicsDeubiquitinase OTUB1 regulates doxorubicin-induced cardiotoxicity
Deubiquitinase OTUB1 regulates doxorubicin-induced cardiotoxicity
PRJNA1005939 | ENA
Sort   by:  
 Page size