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MetabolomicsMulti-country metabolic signature discovery for chicken health classification

INTRODUCTION: To decrease antibiotic resistance, their use as growth promoters in the agricultural sector has been largely abandoned. This may lead to decreased health due to infectious disease or microbiome changes leading to gut inflammation.

OBJECTIVES: ...

2023-08-08 | MTBLS5065 | MetaboLights
MetabolomicsEvidence of a DHA signature in the lipidome and metabolome of human hepatocytes
Cell supplementation with bioactive molecules often causes a perturbation in the whole intracellular environment. Omics techniques can be applied for the assessment of this perturbation. In this study, the overall effect of docosahexaenoic acid (DHA) supplementation on cultured human hepatocyte lipi...
2017-03-02 | MTBLS419 | MetaboLights
MetabolomicsMetabolic signature of idiopathic inflammatory myopathy
Not available
ORGANISM(S): Homo sapiens 
ST002196 | MetabolomicsWorkbench
MetabolomicsMetabolomic signature of mouse cerebral cortex following Toxoplasma gondii infection

BACKGROUND: The protozoan parasite Toxoplasma gondii infects and alters the neurotransmission in cerebral cortex and other brain regions, leading to neurobehavioral and neuropathologic changes in humans and animals. However, the molecules that contribute to these changes remain l...

2020-04-23 | MTBLS770 | MetaboLights
MetabolomicsA metabolome atlas of mouse brain on the global metabolic signature dynamics following short-term fasting
Calorie restriction (CR) or a fasting regimen is considered one of the most potent non-pharmacological interventions to prevent chronic metabolic disorders, ameliorate autoimmune diseases, and attenuate aging. Despite efforts, the mechanisms by which CR improves health, particularly brain health, ar...
2025-07-31 | MTBLS8006 | MetaboLights
MetabolomicsGut Microbiota and Urine Metabolomics Signature in Autism Spectrum Disorder children from Southern China

To determine the gut microbiota and urine metabolomics signature and identify the regional characteristics in Autism spectrum disorder (ASD), we conducted a cohort study of 88 well-characterized participants from Guangxi Zhuang Autonomous Region in Southern China. Gut microbiota and urine metabo...

2025-06-16 | MTBLS12605 | MetaboLights
MetabolomicsMetabolomic fingerprinting of bull spermatozoa for identification of fertility signature metabolites
The objective of the study was to identify the fertility-associated metabolites in bovine spermatozoa using liquid chromatography-mass spectrometry (LC-MS). Six Holstein Friesian crossbred bulls (three high-fertile and three low-fertile bulls) were the experimental animals. Sperm proteins were isola...
2021-12-07 | MTBLS1071 | MetaboLights
MetabolomicsA serum nuclear magnetic resonance-based metabolomic signature of antiphospholipid syndrome
Antiphospholipid syndrome (APS) is a rheumatic inflammatory chronic autoimmune disease inducing hypercoagulable state associated with vascular thrombosis and pregnancy loss in women. Cardiac, cerebral and vascular strokes in these patients are responsible for reduction in life expectancy. Timely dia...
2017-09-06 | MTBLS356 | MetaboLights
MetabolomicsMetabolomic Signature of Early Vascular Aging (EVA) in Hypertension

Arterial stiffening is a hallmark of early vascular aging (EVA) syndrome and an independent predictor of cardiovascular morbidity and mortality. In this case-control study we sought to identify plasma metabolites associated with EVA syndrome in the setting of hypertension. An untargeted metabolom...

2020-01-14 | MTBLS1359 | MetaboLights
MetabolomicsUntargeted metabolomics identifies a plasma sphingolipid-related signature associated with lifestyle intervention in prepubertal children with obesity

OBJECTIVE: Childhood obesity is a strong risk factor for adult obesity and metabolic diseases, including type 2 diabetes and cardiovascular disease. Early lifestyle intervention in children with obesity reduces future disease risk. The objective of this study is to identify metab...

2018-02-09 | MTBLS423 | MetaboLights
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