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TranscriptomicsComplex regulation of the PEP carboxykinase gene pck and characterization of its GntR-type regulator IolR as a repressor of myo-inositol utilization genes in Corynebacterium glutamicum
DNA affinity chromatography with the promoter region of the Corynebacterium glutamicum pck gene, encoding phosphoenolpyruvate carboxykinase (PEPCk), led to the isolation of four transcriptional regulators, i.e., RamA, GntR1, GntR2 and IolR. Determination of the PEPCk activity of the deletion mutant...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2013-07-29 | E-GEOD-44812 | biostudies-arrayexpress
TranscriptomicsThe two-component system ChrSA is crucial for heme tolerance and interferes with HrrSA in heme-dependent gene regulation in Corynebacterium glutamicum
We recently showed that the two-component system (TCS) HrrSA plays a central role in the control of heme homeostasis in the Gram-positive soil bacterium Corynebacterium glutamicum. Here, we characterized the function of another TCS of this organism, ChrSA, which exhibits significant sequence similar...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2012-10-31 | E-GEOD-37327 | biostudies-arrayexpress
TranscriptomicsC.glutamicum Δpup mutant senses a stronger iron limitation than the wild type.
Pupylation is a posttranslational protein modification in bacteria resembling ubiquitination in eukaryotes. The prokaryotic ubiquitin-like protein Pup is covalently attached to other proteins via an isopeptide bond between its carboxyterminal glutamate residue and a lysine residue in the target. In ...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2016-04-04 | E-GEOD-64866 | biostudies-arrayexpress
TranscriptomicsC1 metabolism in Corynebacterium glutamicum: an endogenous pathway for oxidation of methanol to carbon dioxide
Methanol is considered as an interesting carbon source in biobased microbial production processes. As Corynebacterium glutamicum is an important host in industrial biotechnology, in particular for amino acid production, we performed studies on the response of this organism to methanol. C. glutamicum...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2013-09-27 | E-GEOD-49936 | biostudies-arrayexpress
TranscriptomicsThe Two-component Signal Transduction System CopRS of Corynebacterium glutamicum is Required for Adaptation to Copper-excess Stress
Copper is an essential cofactor for many enzymes but at high concentrations it is toxic for the cell. Copper ion concentrations ≥50 µM inhibited growth of Corynebacterium glutamicum. The transcriptional response to 20 µM Cu2+ was studied using DNA microarrays and revealed 26 genes that showed a ≥3-f...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2011-09-04 | E-GEOD-27510 | biostudies-arrayexpress
TranscriptomicsPupylated proteins in Corynebacterium glutamicum revealed by MudPIT analysis
In a manner similar to ubiquitin, the prokaryotic ubiquitin-like protein (Pup) has been shown to target proteins for degradation via the proteasome in mycobacteria. However, not all actinobacteria possessing the Pup protein also harbor a proteasome, suggesting fates for pupylated proteins other than...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2014-06-24 | E-GEOD-48038 | biostudies-arrayexpress
TranscriptomicsEvidence for a key role of cytochrome bo3 oxidase in respiratory energy metabolism of Gluconobacter oxydans
The obligatory aerobic acetic acid bacterium Gluconobacter oxydans oxidizes a variety of substrates in the periplasm by membrane-bound dehydrogenases, which transfer the reducing equivalents to ubiquinone. Two quinol oxidases, cytochrome bo3 and cytochrome bd, then catalyze transfer of the electrons...
ORGANISM(S): Gluconobacter oxydans 621H 
2013-07-26 | E-GEOD-47782 | biostudies-arrayexpress
TranscriptomicsInfluence of oxygen limitation, absence of the cytochrome bc1 complex and low pH on global gene expression in Gluconobacter oxydans 621H using DNA microarray technology
The genome-wide transcriptional responses of the strictly aerobic -proteobacterium Gluconobacter oxydans 621H to oxygen limitation, to the absence of the cytochrome bc1 complex, and to low pH were studied using DNA microarray analyses. Oxygen limitation caused expression changes of 486 genes, repres...
ORGANISM(S): Gluconobacter oxydans 621H 
2012-03-23 | E-GEOD-34294 | biostudies-arrayexpress
TranscriptomicsL-Glutamine metabolism and its regulation in C. glutamicum
Corynebacterium glutamicum, a gram-positive soil bacterium used for the industrial production of amino acids such as L-glutamate and L-lysine, is able to use a number of different nitrogen sources, such as ammonium, urea, or creatinine. In this communication, we show that L-glutamine serves as an ex...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2010-10-05 | E-GEOD-19779 | biostudies-arrayexpress
TranscriptomicsMutational analysis of the pentose phosphate pathway and the Entner-Doudoroff pathway in Gluconobacter oxydans reveals improved growth of an edd-eda deletion mutant on mannitol
The obligatory aerobic acetic acid bacterium Gluconobacter oxydans 621H oxidizes sugars and sugar alcohols primarily in the periplasm and only a small fraction is metabolized in the cytoplasm. The latter can occur either via the Entner-Doudoroff pathway (EDP) or via the pentose phosphate pathway (PP...
ORGANISM(S): Gluconobacter oxydans 621H 
2012-07-31 | E-GEOD-38933 | biostudies-arrayexpress
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