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TranscriptomicsTranscription profiling of mouse conditional intestinal epithelial Hnf4Ialpha knockout to investigate the role of HNF4alpha in the adult colon
Background & Aims: HNF4α is an important transcriptional regulator of hepatocyte and pancreatic function. Hnf4α deletion is embryonically lethal with severe defects in visceral endoderm formation, liver maturation and colon development. However, the precise role of this transcription factor in ma...
ORGANISM(S): Mus musculus 
2009-01-13 | E-GEOD-11759 | biostudies-arrayexpress
ProteomicsFunctions of the 12 different isoforms of the hepatocyte nuclear factor 4 alpha (HNF4α)
HNF4α is a nuclear receptor regulating the transcription of genes involved mainly in development, cell differentiation and metabolism. Opposite functions for the two classes of P1 and P2 isoforms of HNF4α have recently been highlighted. These classes include 12 variants of HNF4α that can be expresse...
ORGANISM(S): Homo sapiens (Human) 
2020-04-17 | PXD012146 | Pride
Transcription Proteomics Nuclear receptors Hnf4α Silac Isoforms Colorectal cancer 
ProteomicsQuantitative mass spectrometry analysis of intestinal organoids
Organoids have the potential to bridge 3D cell culture to tissue physiology by providing a model resembling in vivo organs. We propose here a SILAC method to measure protein expression changes in intestinal organoids under different experimental conditions. With the combined use of quantitative mass...
ORGANISM(S): Mus musculus (Mouse) 
2017-09-05 | PXD004607 | Pride
Intestine Organoids Silac Quantitative proteomics 
ProteomicsSubcellular proteomics analysis of different stages of colorectal cancer cell lines
Studying cell differentiation and transformation allows a better understanding of the mechanisms involved in the initiation and the evolution of cancer. The role of proteins which participate in these processes is dependent on their location within the cell. Determining the subcellular localization ...
ORGANISM(S): Homo sapiens (Human) 
2017-04-19 | PXD004879 | Pride
Subcellular proteomics Colorectal cancer Silac Colon 
UnknownAdd-On Treatment With Zilebesiran for Inadequately Controlled Hypertension: The KARDIA-2 Randomized Clinical Trial.
Not available
S-EPMC12120674 | biostudies-literature
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