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ProteomicsStimulus-specific Immune Modulation by SARS-CoV-2 Nucleocapsid Correlates with Severe COVID-19
A significant proportion of patients with COVID-19 disease, caused by SARS-CoV-2, develop acute respiratory distress syndrome characterized by pro-inflammatory cytokine secretion and dampened IFN-mediated antiviral response. To uncover the mechanisms by which SARS-CoV-2 drives this dysregulation, we...
ORGANISM(S): Homo sapiens (Human) Severe acute respiratory syndrome coronavirus 2 
2026-06-25 | PXD067631 | Pride
Sars-cov-2 Macrophages Nf-kb pathways Nucleocapsid (n) Pro-inflammatory responses 
ProteomicsPhosphoproteomics of Natural Killer (NK) Cells Stimulated with Fibrin and IL-15
Phosphoproteomic analysis of fibrin or IL-15 treated NK cells with timsTOF HT
ORGANISM(S): Homo sapiens (Human) 
2024-06-26 | PXD049692 | Pride
Timstof ht Nk cells Phoshoproteomics 
ProteomicsDUSP12 promotes cell cycle progression and protects cells from cells from ZNF622 mediated apoptosis
Protein phosphatases are critical for regulating cell signaling, cell cycle, and cell fate decisions, and their dysregulation leads to an array of human diseases like cancer. The dual specificity phosphatases (DUSPs) have emerged as important factors driving tumorigenesis and cancer therapy resistan...
ORGANISM(S): Homo sapiens (Human) 
2026-04-06 | PXD072946 | Pride
Dusp12 Proteomics Znf622 Phosphorylation Phosphoproteomics 
ProteomicsPlasma proteomics of Ghanian children from high malaria transmission (HMT) and low malaria transmission (LMT) zones
We performed a longitudinal study of the plasma proteome of children infected with malaria and residing in low or high malaria transmission areas in Ghana. A mass spectrometry-based approach was used to identify putative protein-based biomarkers and predictors of resistance to malaria. Our findings ...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum 
2025-02-11 | PXD060218 | Pride
Plasma Malaria Children Blood 
ProteomicsParacrine Signals from HIV-1 Infected Immune Cells Reprogram Cervical Cancer Pathways
Co-infection of human papillomavirus (HPV) and human immunodeficiency virus type 1 (HIV-1) in women have a six-fold higher risk of developing cervical cancer compared to those without HIV. To evaluate how paracrine signals from HIV-infected T-cells remodeled the proteome of cervical epithelial cells...
ORGANISM(S): Homo sapiens (Human) 
2026-05-05 | PXD077909 | Pride
Hpv-associated cervical cancer Mapk and pi3k signaling Network propagation 
ProteomicsParacrine Signals from HIV-1 Infected Immune Cells Reprogram Cervical Cancer Pathways
Co-infection of human papillomavirus (HPV) and human immunodeficiency virus type 1 (HIV-1) in women have a six-fold higher risk of developing cervical cancer compared to those without HIV. To evaluate how paracrine signals from HIV-infected T-cells remodeled the proteome of cervical epithelial cell...
ORGANISM(S): Homo sapiens (Human) 
2026-06-25 | PXD064529 | Pride
Hpv/hiv coinfection Hpv-associated cervical cancer Mapk and pi3k signaling Network propagation 
ProteomicsProteomics and phosphoproteomics analysis primary human airway epithelial cells exposed to unflavored electronic cigarette smoke
Phosphoproteomics analysis following unflavored e-cigarette exposed donor-derived primary lung epithelial cells from one donor and 3 technical replicates condition using a Bruker timsTOF HT mass spectrometer paired to a ThermoScientific Vaquish Neo HPLC. Conditions were room air (“Air”) or vape (“Va...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD059015 | Pride
Phosphoproteomics Primary lung cells Cigarette exposure 
ProteomicsThe ULK1-NCOA3 axis restrains de novo lipogenesis and prevents progression of MASLD
Metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MASH) are leading causes of cirrhosis and hepatocellular carcinoma. Defects in autophagy contribute to the development of MASLD, however, the role of the Unc-51-like autophagy-activating kinase 1 (ULK1) in the path...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-26 | PXD072418 | Pride
TranscriptomicsRNA-seq time-course of Calu-3 cells infected with SARS-CoV-2 early-lineage and Alpha variant viruses
Emergence of SARS-CoV-2 variants of concern (VOCs), including the globally successful Alpha (B.1.1.7) variant, suggests viral adaptation to enhance human-to-human transmission. Although much effort has focused on characterisation of spike changes, Alpha mutations outside spike likely contribute to a...
ORGANISM(S): Homo sapiens 
2021-12-31 | E-MTAB-11275 | biostudies-arrayexpress
ProteomicsGlobal surface proteomes of hPSC-derived brain microvascular endothelial-like cells (hPSC-BMELCs), human cerebral microvascular endothelial cell line D3 (HCMEC/D3), and human umbilical vein endothelial cells (HUVECs)
Abundance proteomics analysis was performed to characterize the surface proteome of three cell lines: hPSC-BMELCs, a stem cell derived model for human blood-brain barrier endothelial cells; HCMEC/D3, an immortalized cell line of brain microvascular endothelial cells; and HUVECs, primary human endoth...
ORGANISM(S): Homo sapiens (Human) 
2025-11-09 | PXD059899 | Pride
Abundance proteomics Receptors Endothelial cells Surface proteome 
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