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ProteomicsOptimized Time-segment Acquisition Expands Peptide and Protein Identification in TIMS-TOF Pro Mass Spectrometry
We introduce a novel approach, termed time-segment acquisition (Seg), to enhance the identification of peptides and proteins in trapped ion mobility spectrometry (TIMS)-Time of flight (TOF) mass spectrometry. Our method exploits the positive correlation between ion mobility values and liquid chromat...
ORGANISM(S): Homo sapiens (Human) 
2024-12-22 | PXD051790 | Pride
Phosphoproteomics Timstof Ion mobility ms Tims Proteomics 
ProteomicsPhosphoproteomics of Natural Killer (NK) Cells Stimulated with Fibrin and IL-15
Phosphoproteomic analysis of fibrin or IL-15 treated NK cells with timsTOF HT
ORGANISM(S): Homo sapiens (Human) 
2024-06-26 | PXD049692 | Pride
Timstof ht Nk cells Phoshoproteomics 
ProteomicsThe pseudokinase TRIB3 controls adipocyte lipid homeostasis and proliferation in vitro and in vivo
Objective: In vivo studies in humans and mice have implicated the pseudokinase Tribbles 3 (TRIB3) in various aspects of energy metabolism. Whilst cell-based studies indicate a role for TRIB3 in adipocyte differentiation and function, it is unclear if and how these cellular functions may contribute t...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-26 | PXD046703 | Pride
Tribbles  adipocyte  omics analyses  metabolism 
ProteomicsUsing CRISPR-Cas9/Phosphoproteomics to Identify Kinase Substrates: Calmodulin Kinase 2 Delta
The Ca2+/CaM-dependent protein kinase 2 (CAMK2) family of protein kinases are key protein kinases involved in regulation of cellular processes in a variety of tissues including brain, smooth muscle and kidney. One member, CAMK2-delta (CAMK2D), has been proposed to be involved in vasopressin signali...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-06 | PXD040159 | Pride
Mass spectrometry Camk2d Vasopressin Aqp2 
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