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TranscriptomicsExpression data from mouse collecting duct cell, mpkCCD, in response to a peptide hormone vasopressin analog, dDAVP
Vasopressin is the major hormone that regulates renal water excretion. It does so by binding to a receptor in renal collecting duct cells, triggering signaling pathways that ultimately regulate the abundance, location, and activity of the water channel protein aquaporin 2. We took an advantage of ...
ORGANISM(S): Mus musculus 
2010-12-09 | E-GEOD-19938 | biostudies-arrayexpress
TranscriptomicsTranscriptome of a mouse kidney cortical collecting duct cell line: effects of aldosterone and vasopressin
In this study, we analyzed the transcriptome of a highly differentiated mouse clonal CCD principal cell line (mpkCCD(cl4)) and the changes in the transcriptome induced by aldosterone and vasopressin. Serial analysis of gene expression (SAGE) was performed on untreated cells and on cells treated with...
ORGANISM(S): Mus musculus 
2003-09-24 | E-GEOD-678 | biostudies-arrayexpress
TranscriptomicsVasopressin (AVP) and the V2R specific agonist dDAVP 7 day infusion into Aquaporin 1 knockout animals
Vasopressin, the antidiuretic hormone, acts on the renal collecting duct. In this experiment both vasopressin (AVP) and the V2R specific agonist dDAVP were infused into Aquaporin 1 knockout animals for 7 days. The aim of the experiment was to identify genes increased by vasopressin receptors in the ...
ORGANISM(S): Mus musculus 
2007-10-06 | E-GEOD-5953 | biostudies-arrayexpress
ProteomicsSignaling Pathways in Vasopressin-Mediated Regulation of Aquaporin-2
Vasopressin controls water excretion by regulating the water channel protein, aquaporin 2. Vasopressin acts in the renal collecting duct by binding to a G-protein coupled receptor and activating protein kinase A (PKA). Signaling events beyond PKA are largely unknown. Ultra-deep phosphoproteomic anal...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-05-25 | PXD011245 | Pride
Collecting duct Lc-ms/ms Phosphorylation 
GenomicsCombined RNA-seq and Polr2a ChIP-seq Identifies Gene Targets for Transcriptional Regulation in Vasopressin-Sensitive Collecting Duct Cells
In mammals, the peptide hormone vasopressin controls renal water excretion, largely through its actions in the renal collecting duct to regulate the molecular water channel aquaporin-2 (AQP2). There are two modes of regulation: 1) short-term regulation by membrane trafficking; and 2) long-term regu...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-79573 | biostudies-arrayexpress
ProteomicsQuantitative Phosphoproteomic Identification of Novel Vasopressin-mediated Signaling Networks in Kidney Distal Convoluted Tubule Cells
The kidney distal convoluted tubule (DCT) plays an important role in body sodium regulation and thus control of blood pressure. The main sodium reabsorption pathways in the DCT are the epithelial sodium channel (ENaC) and the thiazide-sensitive NaCl cotransporter (NCC), the functions of which can be...
ORGANISM(S): Mus musculus (Mouse) 
2015-08-04 | PXD001729 | Pride
Phosphoproteomics Vasopressin Signaling networks Quantitation Kidney distal convoluted tubule cells 
GenomicsGlucocorticoid receptor maintains vasopressin responses in kidney collecting duct cells
Glucocorticoid receptor maintains vasopressin responses in kidney collecting duct cells
PRJNA798899 | ENA
ProteomicsPKA-Independent Vasopressin Signaling in Renal Collecting Duct
Vasopressin regulates renal water excretion by binding to the Gs-coupled vasopressin receptor (V2R) in collecting duct cells, resulting in cyclic AMP-dependent increases in epithelial water permeability through regulation of the aquaporin-2 (AQP2) water channel. Our prior studies showed that CRISPR...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-05 | PXD015719 | Pride
Mpkccd Phosphoproteomics Ampk Silac Prm-ms 
GenomicsTime-course transcriptome profiling in vasopressin-treated mouse kidney collecting duct mpkCCD
Time-course transcriptome profiling in vasopressin-treated mouse kidney collecting duct mpkCCD
PRJNA686780 | ENA
TranscriptomicsCombined RNA-seq and ChIP-seq Identifies Gene Targets for Transcriptional Regulation in Vasopressin-Sensitive Collecting Duct Cells [RNA-seq]
We sequenced mRNAs and mapping the binding of RNA polymerase 2 in collecting duct cells treat with Vasopressin or vehicle. Confluent mpkCCD cell monolayers were maintained in serum-free medium for 24 h prior to treatment with or without 0.1 nM dDAVP in serum-free medium for 24 h. followed RNA polym...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-79525 | biostudies-arrayexpress
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