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TranscriptomicsComparison of aCGH profiles from KB1(185stop)P, KB1(5382stop)P and KB1P mouse mammary tumors
While BRCA-related cancers respond well to double-strand break (DSB) inducing agents, resistance is a serious clinical problem. One mechanism of resistance is reversion of the BRCA1 mutation, suggesting that BRCA1 function is required for resistance. Here we show that secondary Brca1 mutations are n...
ORGANISM(S): Mus musculus 
2013-12-01 | E-GEOD-43997 | biostudies-arrayexpress
TranscriptomicsEffect of ARF on the transcription of p53 target genes in homologous recombination deficient cells
ARF is a tumour suppressor activated by oncogenic stress, which stabilizes p53. Although p53 is a key component of the response to DNA damage, a similar function for ARF has not been ascribed. In this work we show that homologous recombination (HR) -deficient primary mouse and human cells accumulate...
ORGANISM(S): Mus musculus 
2014-12-04 | E-GEOD-51354 | biostudies-arrayexpress
TranscriptomicsaCGH analysis of Palb2GT/+;p53-/- and Palb2+/+;p53-/- lymphomas
Palb2 interacts with BRCA1 and BRCA2 in supercomplexes involved in DNA repair via homologous recombination. Heterozygous germline mutations in PALB2 confer a moderate risk of breast cancer while biallelic PALB2 mutations are linked to a severe form of Fanconi anaemia characterized by early childhood...
ORGANISM(S): Mus musculus 
2011-01-21 | E-GEOD-26723 | biostudies-arrayexpress
TranscriptomicsSuppression of BRCA1 sensitizes to proteasome inhibitors in DNA repair-independent manner.
Germline and somatic mutations in BRCA1predispose to breast cancer. We found that proteasome inhibitors can selectively kill BRCA1-depleted cells. The toxic response involves a deregulation of the G1/S cell cycle checkpoint via hyperphosphorylation of RB1, 53BP1-mediated arrest at G2/M checkpoint, ...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-56280 | biostudies-arrayexpress
TranscriptomicsComparison of aCGH profiles from KB1C61GP, KB1P and KP mouse mammary tumors
While BRCA-related cancers respond well to double-strand break (DSB) inducing agents, resistance is a serious clinical problem. One mechanism of resistance is reversion of the BRCA1 mutation, suggesting that BRCA1 function is required for resistance. Here we show that secondary Brca1 mutations are n...
ORGANISM(S): Mus musculus 
2011-12-01 | E-GEOD-30710 | biostudies-arrayexpress
UnknownRandomised multicentre effectiveness trial of rapid syndromic testing by panel assay in children presenting to European emergency departments with acute respiratory infections-trial protocol for the ADEQUATE Paediatric trial.
Not available
S-EPMC11057286 | biostudies-literature
UnknownEffect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.
Not available
S-EPMC7489418 | biostudies-literature
UnknownLopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial.
Not available
S-EPMC8274471 | biostudies-literature
UnknownElective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans.
Not available
S-EPMC7272903 | biostudies-literature
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