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ProteomicsProfiling Neuropeptides in Adrenomedullary Chromaffin Cells: Insights into Regulated Release via Electrical and Chemical Stimulation
Despite longstanding recognition that the adrenal medulla is a major source of catecholamines and opioid peptides, the dynamic co-release of these signaling molecules—and the full complexity of their molecular forms—remains poorly understood. This study addresses this gap by integrating real-time el...
ORGANISM(S): Bos taurus (Bovine) 
2026-06-29 | PXD067807 | Pride
Cyclic voltammetry Proenkephalin Trapped ion mobility spectrometry Neuropeptides release Bovine adrenal slices 
TranscriptomicsBovine cartilage zone arrays
Objective. Identify novel genes and pathways specific to superficial (SZ), middle (MZ) and deep zones (DZ) of normal articular cartilage. Methods. Articular cartilage was obtained from knees of 4 normal human donors. The cartilage zones were dissected on a microtome. RNA was analyzed on human genom...
ORGANISM(S): Bos taurus 
2012-07-31 | E-GEOD-39796 | biostudies-arrayexpress
UnknownHigh signal-to-noise imaging of spontaneous and 5 ns electric pulse-evoked Ca2+ signals in GCaMP6f-expressing adrenal chromaffin cells isolated from transgenic mice.
Not available
S-EPMC10065239 | biostudies-literature
TranscriptomicsBovine spongiform encephalopathy infection alters endogenous retrovirus expression in distinct brain regions of cynomolgus macaques (Macaca fascicularis)
Background: Prion diseases such as bovine spongiform encephalopathies (BSE) are transmissible neurodegenerative diseases which are presumably caused by an infectious conformational isoform of the cellular prion protein. Previous work has provided evidence that in murine prion disease the endogenous ...
ORGANISM(S): Macaca fascicularis 
2011-06-10 | E-GEOD-29818 | biostudies-arrayexpress
TranscriptomicsGlobal methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders
Autism is currently considered a multigene disorder with epigenetic influences. To investigate the contribution of DNA methylation to autism spectrum disorders, we have recently completed large-scale methylation profiling by CpG island microarray analysis of lymphoblastoid cell lines (LCL) derived ...
ORGANISM(S): Homo sapiens 
2010-04-27 | E-GEOD-21395 | biostudies-arrayexpress
TranscriptomicsHuman cartilage zone arrays
Objective. Identify novel genes and pathways specific to superficial (SZ), middle (MZ) and deep zones (DZ) of normal articular cartilage. Methods. Articular cartilage was obtained from knees of 4 normal human donors. The cartilage zones were dissected on a microtome. RNA was analyzed on human genom...
ORGANISM(S): Homo sapiens 
2012-07-31 | E-GEOD-39795 | biostudies-arrayexpress
TranscriptomicsKinase activity profiling of human locally advanced rectal cancer samples
Locally advanced rectal cancer characterized by multiplex kinase activity profiling
ORGANISM(S): Homo sapiens 
2010-08-05 | E-TABM-913 | biostudies-arrayexpress
ProteomicsProteomic profiling by array of tyrosine kinase activity in metastatic malignant melanoma from human tissue specimens
Tyrosine kinase activity profiling of metatstatic malignant melanoma and normal skin tissue samples was performed using peptide kinase arrays. All samples were run in triplicates with and withouth inhbitor PLX4032 and Sutent Malate in order to identify how tyrosine kinases responds to kinase inhibit...
ORGANISM(S): Homo sapiens 
2013-01-17 | E-MTAB-1245 | biostudies-arrayexpress
TranscriptomicsExploration of the mechanisms underlying TNF-alpha resistance in breast cancer cells by a transcriptomic approach using an autophagy-dedicated microarray.
We used the autophagy microarray to profile the transcriptome of well-characterized TNF sensitive MCF-7 cell line and corresponding TNF-resistant 1001 clone.
ORGANISM(S): Homo sapiens 
2011-02-28 | E-MEXP-3074 | biostudies-arrayexpress
TranscriptomicsRNA methylation destabilizes developmental regulators in murine embryonic stem cells (m6A)
m6A-seq of mouse embryonic stem cell wildtype or mutant depleted of Mettl3 or Mettl14 m6A-mRNA library for mouse embryonic stem cell each having one biological replicate were generated using HiSeq2000 v3 flowcell (Illumina) and sequenced for 100 bases with separate 7 base indexing read in a single l...
ORGANISM(S): Mus musculus 
2014-01-06 | E-GEOD-46878 | biostudies-arrayexpress
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