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ProteomicsMAP2Ks can activate MAP kinases using ADP in vitro
Kinases are a diverse group of enzymes that use ATP to phosphorylate a variety of substrates. Protein kinases evolved in eukaryotes as important mediators of cell signalling that target specific amino acid side chains to modulate downstream protein function. Among them, the MAPKs (mitogen-activated ...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2025-09-29 | PXD065314 | Pride
Kinase Adp Phosphorylation Mapk 
ProteomicsMolecular basis of mitogen-activated protein kinase ERK2 activation by its upstream kinase MEK1
The RAS-RAF-MEK-ERK mitogen-activated protein kinase (MAPK) pathway relays extracellular signals into a cellular response and its dysregulation leads to many pathologies, particularly cancer. Here, we determined cryo-EM structures of the MAP2K MEK1 activating its substrate MAPK ERK2, the final event...
ORGANISM(S): Homo sapiens (Human) 
2026-10-20 | PXD073457 | Pride
Cellular signalling Protein kinases Phosphorylation 
UnknownUpdate on the third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruited.
Not available
S-EPMC3286387 | biostudies-literature
UnknownThe benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial.
Not available
S-EPMC3386495 | biostudies-literature
UnknownEffect of alteplase on the CT hyperdense artery sign and outcome after ischemic stroke.
Not available
S-EPMC4731690 | biostudies-literature
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