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MetabolomicsMetabolic responses induced by DNA damage and poly (ADP-ribose) polymerase (PARP) inhibition in MCF-7 cells
Genomic instability is one of the hallmarks of cancer. Several chemotherapeutic drugs and radiotherapy induce DNA damage to prevent cancer cell replication. Cells in turn activate different DNA damage response (DDR) pathways to either repair the damage or induce cell death. These DDR pathways also e...
2015-08-01 | MTBLS177 | MetaboLights
MetabolomicsThe Poly (ADP-Ribose) Polymerase inhibitor Veliparib and Radiation Cause Significant Cell Line Dependent Metabolic Changes in Breast Cancer Cells
Breast tumors are characterized into different subtypes based on their surface marker expression, which affects their prognosis and treatment. For example, triple negative breast cancer cells (ER-/PR-/Her2-) show reduced susceptibility towards radiotherapy and chemotherapeutic agents. Poly (ADP-ribo...
2016-11-07 | MTBLS337 | MetaboLights
ProteomicsOxidative stress induced ADP-ribosylome
Oxidative stress is a potent inducer of protein ADP-ribosylation. Although the proteins modified under oxidative stress have been identified, it is not clear, whether the number of modified proteins and/or the number ADP-ribosylation sites varies with stress intensity. Here, we investigated both the...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-11-13 | MSV000080334 | MassIVE
ProteomicsCellular ADP-ribosylome characterization with HCD and EThcD
Protein ADP-ribosylation is a post-translational modification involved in important physiological and pathological processes. Here, we present an optimized method using the Orbitrap Fusion Tribrid mass spectrometer, which drastically improves the overall ADP-ribosylation site localization score and ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-28 | MSV000080008 | MassIVE
GenomicsADP
ADP array data, comprised of 2217 samples of Asian ancestry (excluding the Japanese population from ADP). Samples were genotyped on different Illumina or Affy platform.
EGAD00010001491 | EGA
GenomicsPseudomonas sp. ADP
Evolution of Pseudomonas sp. ADP under atrazine selection pressure
PRJNA296545 | ENA
GenomicsEssential role of poly(ADP-ribosyl)ation in cocaine action
Many of the long-term effects of cocaine on the brain's reward circuitry have been shown to be mediated by alterations in gene expression. Several chromatin modifications, including histone acetylation and methylation, have been implicated in this regulation, but the effect of other histone modifica...
ORGANISM(S): Mus musculus 
2014-02-20 | E-GEOD-55136 | biostudies-arrayexpress
ProteomicsProteomic analyses identify ARH3 as a serine mono-ADP-ribosylhydrolase
ADP-ribosylation is a posttranslational modification that exists in monomeric and polymeric forms. Whereas the writers (e.g. ARTD1/PARP1) and erasers (e.g. PARG, ARH3) of poly-ADP-ribosylation (PARylation) are relatively well described, the enzymes involved in mono-ADP-ribosylation (MARylation) have...
ORGANISM(S): Mus musculus (Mouse) 
2017-12-14 | PXD008083 | Pride
Mef Ethcd Ptm Hcd Parp Mono-adp-ribosyl(-acceptor) hydrolases Arh3 Parg Adp-ribosylation 
TranscriptomicsZinc finger nuclease knockouts of human ADP-glucokinase
Zinc finger nucleases (ZFN) are powerful tools for editing genes in cells. Here we use ZFNs to interrogate the biological function of human ADPGK, which encodes an ADP-dependent glucokinase (ADPGK), in tumour cell lines. The hypothesis tested is that ADPGK utilises ADP to phosphorylate glucose under...
ORGANISM(S): Homo sapiens 
2012-07-19 | E-GEOD-39497 | biostudies-arrayexpress
ProteomicsProteomic characterization of the heart and skeletal muscle reveals widespread Arginine ADP-ribosylation by the ectopic ADP-ribosyltransferase ARTC1
ADP-ribosylation has thus far been studied on the proteomic level mainly in cell lines and in combination with genotoxic stress. The clostridium-like ADP-ribosyltransferases (i.e. ARTC) are GPI-anchored or secreted proteins that are expressed in a highly tissue specific manner. Transcriptomic data r...
ORGANISM(S): Mus musculus (Mouse) 
2018-08-17 | PXD008041 | Pride
Muscle Artc1 Ethcd Ptm Hcd Heart C2c12 Art1 Adp-ribosylation 
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