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GenomicsThioalkalivibrio sp. ARh3
Thioalkalivibrio sp. ARh3
PRJNA176568 | ENA
ProteomicsThe regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome (part 1)
Despite the involvement of Poly(ADP-ribose) polymerase-1 (PARP1) in many important biological pathways, the target residues of PARP1-mediated ADP-ribosylation remain ambiguous. To explicate the ADP-ribosylation regulome, we analyze human cells depleted for key regulators of PARP1 activity, histone P...
ORGANISM(S): Homo sapiens (Human) 
2021-10-07 | PXD023835 | Pride
Parp1 Adpr Hpf1 Arh3 Par Parg Af1521 Mar Adp-ribosylation 
TranscriptomicsComparison of fibroblasts from ARH3-mutated patients and controls by transcription profiling
Mutations in the ARH3 (ADPRHL2) hydrolase that catabolises ADP-ribose are associated with neurodegeneration and ataxia. In our experiments we have found that ARH3-defective cells accumulate mono-(ADP-ribose) scars on histones that may prevent other epigenetic modifications from happening at these si...
ORGANISM(S): Homo sapiens 
2020-11-30 | E-MTAB-8391 | biostudies-arrayexpress
ProteomicsProteomic analyses identify ARH3 as a serine mono-ADP-ribosylhydrolase
ADP-ribosylation is a posttranslational modification that exists in monomeric and polymeric forms. Whereas the writers (e.g. ARTD1/PARP1) and erasers (e.g. PARG, ARH3) of poly-ADP-ribosylation (PARylation) are relatively well described, the enzymes involved in mono-ADP-ribosylation (MARylation) have...
ORGANISM(S): Mus musculus (Mouse) 
2017-12-14 | PXD008083 | Pride
Mef Ethcd Ptm Hcd Parp Mono-adp-ribosyl(-acceptor) hydrolases Arh3 Parg Adp-ribosylation 
ProteomicsARH3-regulated cytokine signaling in MIN6 cells
Analysis of MIN6 murine beta cell line transfected with ARH3 RNAi and treated with pro-inflammatory cytokines TNF-alpha, IL-1beta and IFN-gamma.
ORGANISM(S): Mus musculus (Mouse) 
2024-05-21 | PXD021501 | Pride
Mouse Poly(adp)ribosylation Cytokines Apoptosis Arh3 Min6 beta cells 
ProteomicsThe regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome (part 2)
Despite the involvement of Poly(ADP-ribose) polymerase-1 (PARP1) in many important biological pathways, the target residues of PARP1-mediated ADP-ribosylation remain ambiguous. To explicate the ADP-ribosylation regulome, we analyze human cells depleted for key regulators of PARP1 activity, histone P...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2021-10-11 | PXD027504 | Pride
Parp1 Adpr Hpf1 Arh3 Par Parg Af1521 Mar Adp-ribosylation 
UnknownProteomic analyses identify ARH3 as a serine mono-ADP-ribosylhydrolase.
Not available
S-EPMC5727137 | biostudies-literature
UnknownAI26 inhibits the ADP-ribosylhydrolase ARH3 and suppresses DNA damage repair.
Not available
S-EPMC7535916 | biostudies-literature
UnknownPARP1 inhibition alleviates injury in ARH3-deficient mice and human cells.
Not available
S-EPMC6478412 | biostudies-literature
UnknownStructure-function analyses reveal the mechanism of the ARH3-dependent hydrolysis of ADP-ribosylation.
Not available
S-EPMC6139573 | biostudies-literature
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