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GenomicsGenome wide uH2A localization analysis highlights Bmi1-dependent deposition of the mark at repressed genes.
Polycomb group (PcG) proteins control organism development by regulating the expression of developmental genes. Transcriptional regulation by PcG proteins is achieved at least partly through the PRC2-mediated methylation on lysine 27 of histone H3 (H3K27) and PRC1-mediated ubiquitylation on lysine 1...
ORGANISM(S): Mus musculus 
2009-05-20 | E-GEOD-15896 | biostudies-arrayexpress
TranscriptomicsComparison of the gene expression profiles between MEF, MEF treated with n-Butylenephthalide (BP) 10 and 40ug/ml.
The microarray analysis was used for comparing the gene expression profiles between MEF, MEF treated with n-Butylenephthalide (BP) 10 and 40ug/ml. The total RNA extracted from MEF, MEF treated with n-Butylenephthalide (BP) 10 and 40ug/ml was used for the microarray analysis to compare the gene expre...
ORGANISM(S): Mus musculus 
2014-03-31 | E-GEOD-36289 | biostudies-arrayexpress
TranscriptomicsGene expression changes in mouse embryonic fibroblasts (MEF cells) deficient for Ing1 and Gadd45a
ING1b and GADD45a are nuclear proteins involved in the regulation of cell growth, apoptosis and DNA repair. We found that ING1b and GADD45a physically and functionally interact in the epigenetic regulation of specific target genes. In order to study this interaction further, we analysed the transcri...
ORGANISM(S): Mus musculus 
2013-02-04 | E-GEOD-43318 | biostudies-arrayexpress
TranscriptomicsWild type mouse embryonic fibroblasts (MEF) vs Bax/BAK double knock out MEF treated with and without Nocodazole
MEF WT, MEF DKO(Bax/Bak), MEF DKO(Bax/Bak) expressing rabbit Serca2a, MEF DKO(Bax/Bak) expressing Bak at the endoplasmic reticulum both control and treated with Noco 100 nM for 48h
ORGANISM(S): Mus musculus 
2023-06-12 | E-MTAB-10997 | biostudies-arrayexpress
GenomicsHistone profile for wild type MEF and secondary MEF with Dox-inducible vectors for Klf4, Sox2 and Oct4 (KSO)
Histone profile for wild type MEF and secondary MEF with Dox-inducible vectors for Klf4, Sox2 and Oct4 (KSO). ChIP-Seq data for H3K4me3, H3K27me3 and H3K9me3
ORGANISM(S): Mus musculus 
2010-12-31 | E-GEOD-21271 | biostudies-arrayexpress
TranscriptomicsOct4 and jhdm1b infected MEF with or without vitamin C treatment
Investigate the effect of jhdm1b on Oct4 mediated reprogramming Investigate the effect of vitamin C on the function of jhdm1b oct4 and jhdm1b infected MEF with or without vitamin C treatment
ORGANISM(S): Mus musculus 
2011-11-17 | E-GEOD-32994 | biostudies-arrayexpress
ProteomicsArabidopsis thaliana leaf / E.coli / MEF proteomes label-free shotgun
Proteomic comparison of Arabidopsis thaliana leaf / E.coli / MEF proteomes generated by digestion with legumain, GluC and trypsin.
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) Mus musculus (Mouse) Escherichia coli 
2020-01-20 | PXD014696 | Pride
Arabidopsis thaliana mouse ecoli mef legumain digestion 
ProteomicsMEF cell proteome quantification
Global quantification of the dynamics of proteome and lysine succinylation proteome upon the loss of SDH in MEF cells.
ORGANISM(S): Mus musculus (Mouse) 
2018-02-16 | PXD007874 | Pride
Sdh loss Protein quantification 
TranscriptomicsGene expression data from ahES cells, ES cells, MEF cells and round sperm
Haploid stem cells offer an easy-to-manipulate genetic system and therefore have great values for studies of recessive phenotypes. Here, we show that mouse androgenetic haploid ES (ahES) cell lines can be established by transferring sperm into enucleated oocyte. The ahES cells maintain haploidy and ...
ORGANISM(S): Mus musculus 
2012-08-30 | E-GEOD-39391 | biostudies-arrayexpress
TranscriptomicsElucidating a normal function of huntingtin by analysis of huntingtin-null mouse embryonic fibroblasts
The polyglutamine expansion in huntingtin (Htt) protein is a cause of Huntington’s disease (HD). Htt is an essential gene as deletion of the mouse Htt gene homolog (Hdh) is embryonic lethal in mice. Therefore, in addition to elucidating the mechanisms responsible for polyQ-mediated pathology, it i...
ORGANISM(S): Mus musculus 
2008-04-12 | E-GEOD-11139 | biostudies-arrayexpress
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